Galactose elimination capacity in the rat.
Galactose elimination capacity in the rat.
复制标题
大鼠的半乳糖消除能力。
DOI：
10.3109/00365517309082437
复制
发表时间：
1973
影响因子：
2.1
通讯作者：
S. Keiding
中科院分区：
文献类型：
--
作者：
S. Keiding
半乳糖在大鼠体内的消除符合饱和动力学，估计最大消除速率为122 μmol / h， 200 g体重，估计半饱和浓度0.4 mmol/1。半乳糖消除能力（GEC）定义为血药浓度在6 ~ 20倍Km时测定的消除率。多元回归分析表明，体重和肝脏重量是GEC的决定因素。肝脏组织中半乳糖代谢物的消除率与浓度的关系表明，半乳糖的磷酸化在半乳糖代谢中起限速作用。
The elimination of galactose infused in rats was found to follow saturation kinetics with estimated maximal elimination rate 122 μmol per h and 200 g body weight and estimated half saturation concentration 0.4 mmol/1. The galactose elimination capacity (GEC) is defined as the elimination rates determined at blood concentrations between 6 and 20 time Km. Multiple regression analysis demonstrates that both body weight and liver weight are determining for GEC. The relation between elimination rate and concentration of galactose metabolites in liver tissue indicates that the phosphorylation of galactose is rate limiting in the metabolism of galactose.