Nasal instillation of probiotic extracts inhibits experimental allergic rhinitis
Nasal instillation of probiotic extracts inhibits experimental allergic rhinitis
复制标题
益生菌提取物鼻滴可抑制实验性过敏性鼻炎。
DOI：
10.2217/imt-2019-0119
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发表时间：
2019-10-01
期刊：
影响因子：
2.8
通讯作者：
Yang, Ping-Chang
中科院分区：
文献类型：
--
作者：
Zeng, Xian-Hai;Yang, Gui;Yang, Ping-Chang
目的：变应性鼻炎是一种常见病。AR的治疗效果有待提高。本研究旨在评估局部给予益生菌提取物对实验性AR的抑制作用。方法：在培养物中暴露于丁酸梭菌提取物（CBe），诱导上皮细胞（ECs）上调IL-10的表达。建立小鼠AR模型，评估CBe对AR的治疗潜力。结果：CBe显著诱导ECs中IL-10的表达。未成熟B细胞与cbe引物的ECs共培养可显著提高B细胞（iB10细胞）中IL-10的表达。iB10细胞具有抑制效应CD4(+) t细胞增殖的免疫抑制功能。用含CBe的滴鼻液治疗可有效抑制小鼠实验性AR。结论：局部给药CBe能有效抑制实验性AR。
Aim: Allergic rhinitis (AR) is a common disease. The therapeutic efficacy of AR needs to be improved. This study aims to evaluate the effects of local administration of probiotic extracts on inhibiting experimental AR. Methods: Epithelial cells (ECs) were primed by exposing to Clostridium butyricum extracts (CBe) in the culture to upregulate the expression of IL-10. A mouse AR model was developed to assess the therapeutic potential of CBe in AR. Results: CBe markedly induced the expression of IL-10 in ECs. Co-culture of naive B cells with CBe-primed ECs significantly increased IL-10 expression in the B cells (iB10 cells). The iB10 cells showed immune suppressive function in suppressing effector CD4(+) T-cell proliferation. Treatment with nasal drops containing CBe efficiently inhibited experimental AR in mice. Conclusion: Local administration of CBe can efficiently inhibit experimental AR.