Prospective study on quality of life before and after radical radiotherapy in non-small-cell lung cancer
Prospective study on quality of life before and after radical radiotherapy in non-small-cell lung cancer
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DOI：
10.1200/jco.2001.19.8.2123
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发表时间：
2001-04-15
影响因子：
45.3
通讯作者：
Wouters, EFM
中科院分区：
文献类型：
--
作者：
Langendijk, JA;Aaronson, NK;Wouters, EFM
目的：本研究的目的是探讨接受根治性放射治疗（60戈伊）的非小细胞肺癌（NSCLC）患者的呼吸系统症状和生活质量（QoL）的变化。此外，症状缓解和客观肿瘤反应的水平之间的关联，以及与辐射引起的肺部变化，investigated.Patients和方法：一百六十四例患者进入这项前瞻性研究。使用欧洲癌症研究与治疗组织（EORTC）生活质量问卷（QLQ）-C30和EORTC QLQ-LC '13调查QoL的变化。结果：治疗后患者的生活质量有效率分别为：咯血优（83%），胸痛良（68%），臂肩痛良（63%），食欲减退良（60%）;呼吸困难（37%）、咳嗽（31%）和乏力（28%）较差。QLQ-C30的五个功能量表的QoL应答率从身体和角色功能的35%到社会和认知功能的55%不等。总体QoL的缓解率为36%。发现肿瘤反应与胸痛、手臂/肩部疼痛和身体功能缓解之间存在显著相关性。在放疗期间，最一般的症状和功能和生活质量恶化显着增加noted.Conclusion：这项研究是第一次描述姑息治疗和生活质量的变化，在根治性照射的非小细胞肺癌患者。根治性放疗可以缓解呼吸道症状，并改善大部分预后相对较好的非小细胞肺癌患者的生活质量。虽然肿瘤缩小与呼吸道症状的减轻有关，但它不能作为减轻症状的ct替代物。(C)2001年，美国临床肿瘤学会。
Purpose: The purpose of this study was to investigate changes in respiratory symptoms and quality of life (QoL) in patients with non-small-cell lung cancer (NSCLC) receiving radical radiotherapy (60 Gy). Additionally, the association between the level of symptom relief and objective tumor response, as well as with radiation-induced pulmonary changes, was investigated.Patients and Methods: One hundred sixty-four patients were entered onto this prospective study. The European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ)-C30 and EORTC QLQ-LC '13 were used to investigate changes in QoL. Assessments were performed before radiotherapy and 2 weeks, 6 weeks, 3 months, 6 months, and 12 months after the completion of radiotherapy.Results: The QoL response rates were excellent for hemoptysis (83%); good for chest pain (68%), arm/shoulder pain (63%), and appetite loss (60%); and poor for dyspnea (37%), cough (31%), and fatigue (28%). The QoL response rates for the five functioning scales of the QLQ-C30 varied from 35% for physical and role functioning to 55% for social and cognitive functioning. The response rate for global QoL was 36%. A significant association was found between tumor response and palliation of chest pain, arm/shoulder pain, and physical functioning. During radiotherapy, a significant increase for most general symptoms and a deterioration in functioning and QoL were noted.Conclusion: This study is the first to describe palliation and changes in QoL in radically irradiated patients with NSCLC. Radical radiotherapy offers palliation of respiratory symptoms and improved QoL in a substantial proportion of patients with NSCLC who have relatively good prognostic features. Although tumor reduction is associated with palliation of respiratory symptoms, it cannot serve as ct surrogate for palliation. (C) 2001 by American Society of Clinical Oncology.