Associations Between Serum Free Fatty Acid Levels and Incident Diabetes in a 3-Year Cohort Study.
Associations Between Serum Free Fatty Acid Levels and Incident Diabetes in a 3-Year Cohort Study.
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DOI：
10.2147/dmso.s302681
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Zhao J
中科院分区：
文献类型：
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作者：
Li Q;Zhao M;Wang Y;Zhong F;Liu J;Gao L;Zhao J
高循环游离脂肪酸（FFA）与糖尿病的发展有关。本研究旨在评估FFA水平、FFA水平变化和平均FFA水平与糖尿病发病率之间的纵向相关性。这项为期3年的队列研究于2011年至2014年在宁阳进行。在基线和随访结束时测量血清FFA、空腹血糖（FPG）、餐后2小时血糖（2 hPG）和糖化血红蛋白（HbA 1c）水平。采用多元逐步logistic回归模型评估各组血清FFA水平与糖尿病发病风险之间的关系。在2905名基线无糖尿病的个体中，290名在3年随访时发展为糖尿病。随着基线FFA水平的增加，平均FPG、2 hPG和HbA 1c水平以及随访结束时糖尿病患病率增加。FPG和HbA 1c升高趋势无统计学意义。较高的FFA基线水平与糖尿病发病风险的增加无显著相关性。血清FFA水平的纵向变化显示，FFA水平从正常到高（OR = 2.956，95% CI：2.089-4.184）或从高到高（OR = 3.343，95% CI：2.300-4.857）的个体与FFA水平从正常到正常的个体相比，糖尿病发病的风险更大。同样，ΔFFA ≥ 0 mmol/L（OR = 1.762，95%CI：1.373-2.262）或平均血清FFA水平高（OR = 2.120，95%CI：1.620-2.775）的个体发生糖尿病的风险高于ΔFFA < 0 mmol/L或平均血清FFA水平正常的个体。血清游离脂肪酸水平的纵向状态，包括慢性增加和持续高水平，与高基线游离脂肪酸水平相比，与糖尿病发病风险更密切相关。
High circulating free fatty acid (FFA) is associated with the development of diabetes. This study was designed to evaluate longitudinal associations between FFA levels, changes in FFA levels, and mean FFA levels and incident diabetes. This 3-year cohort study was conducted in Ningyang between 2011 and 2014. Serum FFA, fasting blood glucose (FPG), 2-hour postprandial blood glucose (2hPG), and glycosylated hemoglobin (HbA1c) levels were measured at baseline and at the end of follow-up. A multivariate stepwise logistic regression model was used to evaluate associations between serum FFA levels in various groups and the risk of incident diabetes. Of the 2905 individuals without baseline diabetes, 290 developed diabetes by the 3-year follow-up. With increasing baseline FFA levels, the mean FPG, 2hPG, and HbA1c levels, and the prevalence of diabetes at the end of follow-up increased. The trend of FPG and HbA1c increase was not statistically significant. Higher baseline FFA levels were not significantly associated with greater risk of incident diabetes. However, longitudinal changes in serum FFA levels showed that individuals with serum FFA levels from normal to high (OR = 2.956, 95% CI: 2.089–4.184) or from high to high (OR = 3.343, 95% CI: 2.300–4.857) had greater risk of incident diabetes compared with those with normal to normal FFA levels. Similarly, individuals with ΔFFA ≥ 0 mmol/L (OR = 1.762, 95% CI: 1.373–2.262) or high mean serum FFA levels (OR = 2.120, 95% CI: 1.620–2.775) were at higher risk of incident diabetes than those with ΔFFA < 0 mmol/L or normal mean serum FFA levels. The longitudinal status of serum FFA levels, including chronic increases and sustained high levels, was more closely associated with high risk of incident diabetes than was high baseline FFA levels.