Uptake and Tissue Distribution of Pharmaceuticals and Personal Care Products in Wild Fish from Treated-Wastewater-Impacted Streams.
Uptake and Tissue Distribution of Pharmaceuticals and Personal Care Products in Wild Fish from Treated-Wastewater-Impacted Streams.
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DOI：
10.1021/acs.est.5b02478
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发表时间：
2015-09
影响因子：
11.4
通讯作者：
R. Tanoue;K. Nomiyama;Haruna Nakamura;Joon-Woo Kim;T. Isobe;R. Shinohara;T. Kunisue;S. Tanabe
中科院分区：
文献类型：
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作者：
R. Tanoue;K. Nomiyama;Haruna Nakamura;Joon-Woo Kim;T. Isobe;R. Shinohara;T. Kunisue;S. Tanabe
鱼类等离子体模型（FPM）是一种筛选野生鱼类潜在危险药物的技术。然而，这种方法不能解释种间或种内药代动力学和药效学参数的变异性。本研究阐明了20种药物和个人护理用品（PPCP）残留在生活在污水处理过的河流中的野生鲤类鱼体内的吸收效力、组织分布和生物风险。为了明确PPCPs的FPM的不确定性，我们比较了现场的等离子体生物积累因子（BAFplasma =实测鱼体/环境水浓度比）和实际环境下的预测等离子体生物富集因子（BCFplasma =利用理论分配系数预测的鱼体/环境水浓度比）。结果，炎性因子的最大BCFplasma测量值高达理论BCFplasma值的17倍，导致可能低估了野生鱼类的毒理学风险。当估计PPCPs的组织-血液分配系数（组织/血液浓度比）时，发现精神药物进入组织，特别是大脑的可转运性更高，但个体鱼的脑/血浆比率差异很大（高达28倍）。在本研究中，我们提供了关于PPCP药代动力学的种内变异性的有价值的数据集，我们的结果强调了测定PPCP在可能的靶器官和血液中的浓度对于评估PPCP对野生鱼类的风险的重要性。
A fish plasma model (FPM) has been proposed as a screening technique to prioritize potential hazardous pharmaceuticals to wild fish. However, this approach does not account for inter- or intraspecies variability of pharmacokinetic and pharmacodynamic parameters. The present study elucidated the uptake potency (from ambient water), tissue distribution, and biological risk of 20 pharmaceutical and personal care product (PPCP) residues in wild cyprinoid fish inhabiting treated-wastewater-impacted streams. In order to clarify the uncertainty of the FPM for PPCPs, we compared the plasma bioaccumulation factor in the field (BAFplasma = measured fish plasma/ambient water concentration ratio) with the predicted plasma bioconcentration factor (BCFplasma = fish plasma predicted by use of theoretical partition coefficients/ambient water concentration ratio) in the actual environment. As a result, the measured maximum BAFplasma of inflammatory agents was up to 17 times higher than theoretical BCFplasma values, leading to possible underestimation of toxicological risk on wild fish. When the tissue-blood partition coefficients (tissue/blood concentration ratios) of PPCPs were estimated, higher transportability into tissues, especially the brain, was found for psychotropic agents, but brain/plasma ratios widely varied among individual fish (up to 28-fold). In the present study, we provide a valuable data set on the intraspecies variability of PPCP pharmacokinetics, and our results emphasize the importance of determining PPCP concentrations in possible target organs as well as in the blood to assess the risk of PPCPs on wild fish.