The Pareidolia Test: A Simple Neuropsychological Test Measuring Visual Hallucination-Like Illusions.
The Pareidolia Test: A Simple Neuropsychological Test Measuring Visual Hallucination-Like Illusions.
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DOI：
10.1371/journal.pone.0154713
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Mori E
中科院分区：
文献类型：
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作者：
Mamiya Y;Nishio Y;Watanabe H;Yokoi K;Uchiyama M;Baba T;Iizuka O;Kanno S;Kamimura N;Kazui H;Hashimoto M;Ikeda M;Takeshita C;Shimomura T;Mori E
视觉幻觉是路易体痴呆的一个核心临床特征，这一症状在鉴别诊断和预测治疗效果方面具有重要意义。妄想症测试是一种唤起类似幻觉的视觉错觉的工具，这些错觉可能是DLB中视觉幻觉的替代标记。我们创建了简化版本的Pareidolia测试，并检查了其有效性和可靠性，以确定该测试的临床实用价值。对52例DLB患者、52例阿尔茨海默病(AD)患者和20例健康对照(HCS)进行了Pareidolia测试。我们使用组内相关系数(ICC)和以神经精神病学问卷(NPI)幻觉评分为参考的同时效度来评估重测/评分者间的信度。受试者操作特征(ROC)分析用于评估Pareidolia试验区分DLB与AD和HCS的敏感性和特异性。Pareidolia测试需要大约15分钟的时间，表现出良好的重测/评分者间可靠性(ICC为0.82)，与NPI幻觉评分中等相关(rS=0.42)。根据ROC分析和Pareidolia试验的最佳分界值，区分DLB和AD的敏感度为81%，特异度为92%。我们的研究表明，简化版的妄想症测试是一种有效和可靠的替代标记的视觉幻觉在DLB。
Visual hallucinations are a core clinical feature of dementia with Lewy bodies (DLB), and this symptom is important in the differential diagnosis and prediction of treatment response. The pareidolia test is a tool that evokes visual hallucination-like illusions, and these illusions may be a surrogate marker of visual hallucinations in DLB. We created a simplified version of the pareidolia test and examined its validity and reliability to establish the clinical utility of this test. The pareidolia test was administered to 52 patients with DLB, 52 patients with Alzheimer’s disease (AD) and 20 healthy controls (HCs). We assessed the test-retest/inter-rater reliability using the intra-class correlation coefficient (ICC) and the concurrent validity using the Neuropsychiatric Inventory (NPI) hallucinations score as a reference. A receiver operating characteristic (ROC) analysis was used to evaluate the sensitivity and specificity of the pareidolia test to differentiate DLB from AD and HCs. The pareidolia test required approximately 15 minutes to administer, exhibited good test-retest/inter-rater reliability (ICC of 0.82), and moderately correlated with the NPI hallucinations score (rs = 0.42). Using an optimal cut-off score set according to the ROC analysis, and the pareidolia test differentiated DLB from AD with a sensitivity of 81% and a specificity of 92%. Our study suggests that the simplified version of the pareidolia test is a valid and reliable surrogate marker of visual hallucinations in DLB.