Growth regulation of Gardner's syndrome colorectal cancer cells by NSAIDs.
Growth regulation of Gardner's syndrome colorectal cancer cells by NSAIDs.
复制标题
非甾体抗炎药对加德纳综合征结直肠癌细胞的生长调节。
DOI：
10.1007/978-1-4899-1813-0_64
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发表时间：
1997
影响因子：
--
通讯作者：
Boman,B
中科院分区：
文献类型：
--
作者：
Hughes-Fulford,M;Boman,B
The use of NSAIDs (non-steroidal anti-inflammatory drugs) has been shown to reduce risk of mortality from colorectal cancer. It is not known how NSAIDs inhibit the growth of colorectal cancer, and whether this inhibition of growth is mediated through its action on the enzymatic activity of the cyclo-oxygenenases, (COX) which are responsible for prostaglandin synthesis. NSAIDs have been shown to reduce the size and number of colorectal cancer lesions in familial adenomatous polyposis patients. We present data that suggest that the COX product, prostaglandin E2, plays a key role in regulation which supports cell proliferation in cancer. In this study, we analyzed gene expression of COX-2 in concert with cell growth in order to study the mechanism of NSAID inhibition of growth of colorectal carcinoma cells derived from familial adenomatous polyposis patients.
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DOI：
10.1016/s0021-9258(18)53338-x
发表时间：
1993-03
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Dean A. KujubuSgT;Srinivasa T. ReddyQll;Bradley S. Fletcher;H. R. Herschman
通讯作者：
Dean A. KujubuSgT;Srinivasa T. ReddyQll;Bradley S. Fletcher;H. R. Herschman
Hayaishi, O.：“睡眠和昼夜节律的功能基因组学邀请评论：分子遗传学研究”
DOI：
--
发表时间：
--
期刊：
影响因子：
--
作者：
通讯作者：
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巨噬细胞介导的肿瘤细胞杀伤：前列腺素 E 调节细胞溶解活性的表达。
影响因子：
4.4
作者：
S. Taffet;S. Russell
通讯作者：
S. Russell
前列腺素对 S 期 DNA 合成的非 cAMP 依赖性抑制的证据。
DOI：
--
发表时间：
1983
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Wiley,MH;Feingold,KR;Grunfeld,C;Quesney-Huneeus,V;Wu,JM
通讯作者：
Wu,JM
影响因子：
11.2
作者：
M. E. Gross;M. Zorbas;Y. J. Danels;R. Garcia;G. Gallick;Matilde Olive;M. Brattain;Bruce M. Boman;L. Yeoman
通讯作者：
M. E. Gross;M. Zorbas;Y. J. Danels;R. Garcia;G. Gallick;Matilde Olive;M. Brattain;Bruce M. Boman;L. Yeoman