SYMPTOMATIC AND ASYMPTOMATIC CERVICAL INFECTIONS WITH HUMAN PAPILLOMAVIRUS DURING PREGNANCY
SYMPTOMATIC AND ASYMPTOMATIC CERVICAL INFECTIONS WITH HUMAN PAPILLOMAVIRUS DURING PREGNANCY
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DOI：
10.1093/infdis/156.6.904
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发表时间：
1987-12-01
影响因子：
6.4
通讯作者：
ZWICKL, BW
中科院分区：
文献类型：
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作者：
FIFE, KH;ROGERS, RE;ZWICKL, BW
在一个市中心产科门诊就诊的孕妇人群中，在孕早期确定宫颈人乳头瘤病毒（HPV）感染的患病率。采用三种不同的印迹杂交方法对宫颈刮片标本进行HPV 6、11、16、18和31型DNA筛查。234例患者中有26例（11.1%）的标本含有HPV DNA序列。HPV-16和-31分别在6份标本中检出，而HPV-6、-11和-18分别在3份标本中检出。另外5份标本含有未定型的HPV DNA序列。26例阳性标本中只有2例来自生殖器疣患者;另外12例标本来自细胞学异常患者。我们的结论是，宫颈HPV感染在一些怀孕的人群是常见的，许多这样的感染是不明显的临床。
The prevalence of human papillomavirus (HPV) infection of the cervix was determined in an unselected population of pregnant women presenting to an inner-city Obstetrics Clinic in the first trimester. Cervical scrape specimens were screened for the presence of HPV types 6, 11, 16, 18, and 31 DNA by using three different blot hybridization methods. Specimens from 26 (11.1%) of 234 patients contained HPV DNA sequences. HPV-16 and -31 were detected in six specimens each, whereas HPV-6, -11, and -18 were each identified in three specimens. Five additional specimens contained HPV DNA sequences of undertermined type. Only two of the 26 positive specimens were obtained from patients with genital warts; an additional 12 specimens were from patients with cytological abnormalities. We conclude that cervical HPV infections in some pregnant populations are common and that many such infections are not clinically apparent.