From pattern to process: studies at the interface of gene regulatory networks, morphogenesis, and evolution.
From pattern to process: studies at the interface of gene regulatory networks, morphogenesis, and evolution.
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从模式到过程：基因调控网络、形态发生和进化界面的研究。
DOI：
10.1016/j.gde.2018.08.004
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发表时间：
2018
影响因子：
4
通讯作者：
Davidson,Lance
中科院分区：
文献类型：
--
作者：
Smith,SarahJacquelyn;Rebeiz,Mark;Davidson,Lance
解剖结构的发展是复杂的，从多个基因调控网络（GRN）的基因表达模式开始。这些网络最终调节效应分子的活性，进而改变发育过程中的细胞行为。这些过程一起以生物力学方式产生解剖结构随着时间的推移而采用的三维形状。然而，这些过程之间的接口经常被忽视，并且还包括反直觉的反馈机制。在这篇综述中，我们检查了这个极其复杂的过程中的每一步，并探讨了进化发育生物学模型系统，如蝴蝶鳞片、脊椎动物牙齿和果蝇附属物如何提供一种补充方法，从另一个角度揭示遗传学和形态发生的多因素整合。
The development of anatomical structures is complex, beginning with patterning of gene expression by multiple gene regulatory networks (GRNs). These networks ultimately regulate the activity of effector molecules, which in turn alter cellular behavior during development. Together these processes biomechanically produce the three-dimensional shape that the anatomical structure adopts over time. However, the interfaces between these processes are often overlooked and also include counter-intuitive feedback mechanisms. In this review, we examine each step in this extraordinarily complex process and explore how evolutionary developmental biology model systems, such as butterfly scales, vertebrate teeth, and theDrosophiladorsal appendage offer a complementary approach to expose the multifactorial integration of genetics and morphogenesis from an alternative perspective.