INTERACTION BETWEEN GLUTAMATE AND LUTEINIZING-HORMONE-RELEASING HORMONE (LHRH) IN LORDOSIS BEHAVIOR AND LUTEINIZING-HORMONE RELEASE (LH) - FURTHER-STUDIES ON NMDA RECEPTOR MEDIATION
INTERACTION BETWEEN GLUTAMATE AND LUTEINIZING-HORMONE-RELEASING HORMONE (LHRH) IN LORDOSIS BEHAVIOR AND LUTEINIZING-HORMONE RELEASE (LH) - FURTHER-STUDIES ON NMDA RECEPTOR MEDIATION
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DOI：
10.1016/0031-9384(95)00040-p
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发表时间：
1995-07-01
影响因子：
2.9
通讯作者：
DONOSO, AO
中科院分区：
文献类型：
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作者：
GARGIULO, PA;DONOSO, AO
目前的研究探讨了谷氨酸激动剂 N-甲基-D-天冬氨酸对雌激素引发的卵巢切除大鼠的脊柱前凸反应和 LH 释放的影响。先前在大脑第三脑室 (IVT) 插管的大鼠组接受盐水、NMDA 和 LHRH 的攻击。发现 IVT 施用 0.5、0.75 和 1 ug NMDA 后，脊柱前凸-安装商 (LQ) 明显增加。 LHRH（150 ng IVT）也增强了 LQ。两种情况下血浆 LH 水平均较高。脑室内注射选择性 LHRH 拮抗剂 [D-p-Glu(1)、D-Phe(2)、D-Trp(3,6)]-LHRH (100 ng) 无法阻止 NMDA 对脊柱前凸行为的作用。相反，它减弱了 LHRH 对 LQ 的增强作用。 NMDA 和 LHRH 引起的 LH 释放被 LHRH 拮抗剂阻断。目前的结果支持我们之前的观点，即谷氨酸通过 NMDA 受体参与脊柱前凸行为的调节。谷氨酸似乎通过不同的机制在行为和内分泌模式中发挥作用。第一个似乎不是由 LHRH 介导的，但内分泌效应是通过 LHRH 释放来发挥作用的。
The present studies examine the effects of the glutamate agonist N-Methyl-D-Aspartic acid on lordosis responsiveness and LH release in estrogen-primed, ovariectomized rats. Groups of rats previously cannulated in the 3rd ventricle of the brain (IVT) were challenged with saline, NMDA and LHRH. A clear increase in lordosis-to-mount quotients (LQ) after IVT administration of 0.5, 0.75 and 1 ug NMDA was found. LHRH (150 ng IVT) also enhanced LQ. High plasma LH levels were present in both cases. Intraventricular administration of the selective LHRH antagonist [D-p-Glu(1), D-Phe(2), D-Trp(3,6)]-LHRH (100 ng) was unable to prevent NMDA action on lordosis behavior. In contrast, it blunted LHRH enhancement of LQ. LH release evoked by either NMDA and LHRH was blocked by the LHRH antagonist. Present results support our previous view suggesting that glutamate, through NMDA receptors, participates in the regulation of lordosis behavior. Glutamate seems to exert its actions in the behavioral and endocrine patterns through different mechanisms; the first seems not to be mediated by LHRH, but the endocrine effect operates via LHRH release.