Effects of lamotrigine on the 5-HT1A receptor function in healthy human males.
Effects of lamotrigine on the 5-HT1A receptor function in healthy human males.
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DOI：
10.1016/s0165-0327(98)00008-1
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发表时间：
1998-05
影响因子：
6.6
通讯作者：
I. Shiah;I. Shiah;Lakshmi N. Yatham;Raymond W. Lam;A. Zis
中科院分区：
文献类型：
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作者：
I. Shiah;I. Shiah;Lakshmi N. Yatham;Raymond W. Lam;A. Zis
背景拉莫三嗪是一种新型抗惊厥药，最近有报道对双相躁狂、抑郁和情感障碍患者有效，提示它可能是一种具有抗躁狂和抗抑郁作用的情绪稳定剂。然而，其疗效在情绪disorders.MethodsTo探讨拉莫三嗪的作用机制的5-HT 1A受体的作用，我们测量了体温和血浆皮质醇反应的挑战与选择性5-HT 1A受体激动剂伊沙匹龙在10个健康的人类男性的机制的作用。每名受试者在时间“0”接受0.3mg/kg盐酸伊沙匹龙片剂。在0、30、60、90、120、150、15在用拉莫三嗪治疗1周后重复伊沙匹隆激发试验（100 mg/天）结果拉莫三嗪治疗1周并没有显著改变对伊沙匹隆的低温或皮质醇反应。样本量，低治疗剂量，短的治疗间隔，和缺乏安慰剂controls.ConclusionsOur研究结果可能表明，5-HT 1A受体功能不参与拉莫三嗪在人类的作用机制。需要在更多受试者中进行更高拉莫三嗪剂量和更长治疗间隔的进一步安慰剂对照研究来验证这一点。
BackgroundLamotrigine, a new anticonvulsant, has recently been reported to be effective in treating patients with bipolar mania, depression, and schizoaffective disorder, suggesting that it is perhaps a mood stabilizer with antimanic and antidepressant properties. However, the mechanism of action underlying its efficacy in mood disorders is still unknown.MethodsTo explore the role of 5-HT1Areceptors in the mechanism of action of lamotrigine, we measured the body temperature and plasma cortisol responses to a challenge with a selective 5-HT1Areceptor agonist ipsapirone in ten healthy human males. Each subject received 0.3 mg/kg of ipsapirone hydrochloride tablets at time “0”. Body temperature readings and blood samples for cortisol levels were obtained at 0, 30, 60, 90, 120, 150, 180 min. The ipsapirone challenge tests were repeated after 1 week treatment with lamotrigine (100 mg/day).ResultsTreatment with lamotrigine for 1 week did not significantly alter the hypothermic or cortisol responses to ipsapirone.LimitationsThe limitations of this study included small sample size, low treatment dose, short treatment interval, and lack of placebo control.ConclusionsOur findings might suggest that 5-HT1Areceptor function is not involved in the mechanism of action of lamotrigine in humans. Further placebo-controlled studies with a higher lamotrigine dose and a longer treatment interval in a larger number of subjects are needed to verify this.