Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for acyl-CoA synthetase 4 deficiency
Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for acyl-CoA synthetase 4 deficiency
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DOI：
10.1006/bbrc.2001.5065
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发表时间：
2001-06-22
影响因子：
3.1
通讯作者：
Yamamoto, TT
中科院分区：
文献类型：
--
作者：
Cho, YY;Kang, MJ;Yamamoto, TT
各种刺激释放的花生四烯酸在酰基辅酶A合成酶（ACS）和随后的酰基转移反应的引发下迅速再酯化成膜磷脂。 ACS4 是一种花生四烯酸偏好酶，在类固醇生成组织中含量丰富，被认为可以调节类二十烷酸的产生。 ACS4 缺陷杂合的雌性小鼠怀孕频率较低，且产仔数较少，且破坏等位基因的传播率极低。在ACS4+/-雌性中检测到显着的形态学变化，包括极度增大的子宫和腔内充满大量不同大小的增殖性囊肿。此外，在杂合雌性的子宫中发现前列腺素显着积聚。这些结果表明 ACS4 调节女性生育力和子宫前列腺素的产生。 (C)动物园学术出版社。
Arachidonate released by various stimuli is rapidly reesterified into membrane phospholipids initiated by acyl-CoA synthetase (ACS) and subsequent acyl-transfer reactions. ACS4 is an arachidonate-preferring enzyme abundant in steroidogenic tissues and postulated to modulate eicosanoid production. Female mice heterozygous for ACS4 deficiency become pregnant less frequently and produce small Litters with extremely low transmission of the disrupted alleles. Striking morphological changes, including extremely enlarged uteri and lumina filled with numerous proliferative cysts of various sizes, were detected in ACS4+/- females, Furthermore, marked accumulation of prostaglandins was seen in the uterus of the heterozygous females. These results indicate that ACS4 modulates female fertility and uterine prostaglandin production. (C) zool Academic Press.