Transcriptome of normal lung distinguishes mouse lines with different susceptibility to inflammation and to lung tumorigenesis
Transcriptome of normal lung distinguishes mouse lines with different susceptibility to inflammation and to lung tumorigenesis
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DOI：
10.1016/j.canlet.2010.01.038
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发表时间：
2010-08-28
期刊：
影响因子：
9.7
通讯作者：
Dragani, Tommaso A.
中科院分区：
文献类型：
--
作者：
De Franco, Marcelo;Colombo, Francesca;Dragani, Tommaso A.
AIRmax和AIRmin小鼠系在氨基甲酸乙酯处理后显示出不同的肺部炎症反应和不同的肺部肿瘤易感性。在未处理和经处理的AIRmax和AIRmin小鼠的正常肺组织中分析了类似于24，000个已知基因的转录谱。在未治疗小鼠的肺中，参与诸如“白细胞跨内皮迁移”、“细胞粘附”和“紧密连接”等途径的炎症相关基因差异表达。此外，尿烷处理小鼠的基因表达水平显着不同：在AIRmin小鼠中，参与炎症反应相关途径的基因表达调节与之前观察到的这些小鼠肺部炎症细胞的持续浸润平行。(C)2010爱思唯尔爱尔兰有限公司版权所有。
AIRmax and AIRmin mouse lines show a differential lung inflammatory response and differential lung tumor susceptibility after urethane treatment. The transcript profile of similar to 24,000 known genes was analyzed in normal lung tissue of untreated and urethane-treated AIRmax and AIRmin mice. In lungs of untreated mice, inflammation-associated genes involved in pathways such as "leukocyte transendothelial migration", "cell adhesion" and "tight junctions" were differentially expressed. Moreover, gene expression levels differed significantly in urethane-treated mice: in AIRmin mice, modulation of expression of genes involved in pathways associated with inflammatory response paralleled the previously observed persistent infiltration of inflammatory cells in the lung of these mice. (C) 2010 Elsevier Ireland Ltd. All rights reserved.