Direct evidence for wake-related increases and sleep-related decreases in synaptic strength in rodent cortex.
Direct evidence for wake-related increases and sleep-related decreases in synaptic strength in rodent cortex.
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DOI：
10.1523/jneurosci.1409-10.2010
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发表时间：
2010-06-23
期刊：
影响因子：
--
通讯作者：
Gao XB
中科院分区：
文献类型：
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作者：
Liu ZW;Faraguna U;Cirelli C;Tononi G;Gao XB
尽管有证据表明，清醒与净突触增强有关，睡眠与抑郁有关，但在大脑皮层等大型大脑区域中缺乏突触电流变化的直接证据。通过记录清醒和睡眠状态下小鼠和大鼠额叶皮层脑片的微兴奋性突触后电流（miniature excitatory postsynaptic currents，mEPSCs），发现mEPSCs的频率和振幅在清醒后增加，在睡眠后降低。睡眠剥夺后的恢复睡眠也降低了mEPSC，表明睡眠有利于突触稳态。由于更强的突触需要更多的能量、空间和供应，突触的普遍缩小可能是睡眠的一个重要功能。
Despite evidence that waking is associated with net synaptic potentiation and sleep with depression, direct proof for changes in synaptic currents is lacking in large brain areas such as the cerebral cortex. By recording miniature excitatory postsynaptic currents (mEPSCs) from frontal cortex slices of mice and rats that had been awake or asleep, we found that the frequency and amplitude of mEPSCs increased after wake and decreased after sleep. Recovery sleep after sleep deprivation also decreased mEPSCs, suggesting that sleep favors synaptic homeostasis. Since stronger synapses require more energy, space, and supplies, a generalized downscaling of synapses may be an important function of sleep.