THE POSSIBLE ROLE OF AGE-RELATED INCREASE IN THE PLASMA GLUCAGON/INSULIN RATIO IN THE ENHANCED HEPATIC GLUCONEOGENESIS AND HYPERGLYCEMIA IN GENETICALLY DIABETIC (C57BL/KSJ-DB/DB) MICE
THE POSSIBLE ROLE OF AGE-RELATED INCREASE IN THE PLASMA GLUCAGON/INSULIN RATIO IN THE ENHANCED HEPATIC GLUCONEOGENESIS AND HYPERGLYCEMIA IN GENETICALLY DIABETIC (C57BL/KSJ-DB/DB) MICE
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DOI：
10.1254/jjp.66.281
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发表时间：
1994-11-01
期刊：
影响因子：
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通讯作者：
YAMAGUCHI, I
中科院分区：
文献类型：
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作者：
KODAMA, H;FUJITA, M;YAMAGUCHI, I
对遗传性糖尿病db/db小鼠及其血糖正常的同窝小鼠（+/+小鼠）进行了研究，以测定血糖、胰高血糖素和胰岛素的血浆水平以及肝促血管生成酶活性。5周龄db/db和+/+小鼠之间的血糖水平没有显著差异，但前者随着年龄的增长而增加，直到动物16周龄。葡萄糖-6-磷酸酶（G-6-ATPase）和果糖-1，6-二磷酸酶（F-1，6-DATPase）的活性也观察到类似的年龄相关变化。虽然在7周龄时达到峰值的胰岛素和胰高血糖素的血浆水平与高血糖症不平行，但血浆胰高血糖素/胰岛素（G/I）比大致与高血糖症平行。db/db小鼠的个体值分析显示具有统计学显著性（P
Genetically diabetic db/db mice and their normoglycemic littermates (+/+ mice) were studied to determine plasma levels of glucose, glucagon and insulin and hepatic gluconeogenic enzyme activities. Plasma glucose levels did not differ significantly between the 5-week-old db/db and +/+ mice, but increased with age in the former until the animals were 16-week-old. Similar age-associated changes were observed in the activities of the gluconeogenic enzymes, glucose-6-phosphatase (G-6-Pase) and fructose-1,6-diphosphatase (F-1,6-DPase). While the plasma levels of insulin and glucagon that peaked at 7 weeks of age did not parallel the hyperglycemia, the plasma glucagon/insulin (G/I) ratio roughly paralleled the hyperglycemia. Analysis of individual values for the db/db mice revealed statistically significant (P