The pro-inflammatory cytokine interleukin-18 impairs long-term potentiation and NMDA receptor-mediated transmission in the rat hippocampus in vitro
The pro-inflammatory cytokine interleukin-18 impairs long-term potentiation and NMDA receptor-mediated transmission in the rat hippocampus in vitro
复制标题
DOI：
10.1016/s0306-4522(01)00405-5
复制
发表时间：
2001-01-01
期刊：
影响因子：
3.3
通讯作者：
O'Connor, JJ
中科院分区：
文献类型：
--
作者：
Curran, B;O'Connor, JJ
研究了促炎细胞因子白细胞介素-18（IL-18）对正常和分离的N-甲基-D-天冬氨酸（NMDA）受体介导的场兴奋性突触后电位（fEPSP）的影响以及对大鼠齿状回长时程增强（LTP）的诱导作用。在高频刺激前用IL-18（100 ng/ml）浴灌流20 min对基线突触传递或成对脉冲抑制没有显著影响，但确实损害了LTP的诱导（115.7 +/- 8.8%对150.8 +/- 8.1%，赋形剂对照切片，n=6，P
The effects of the pro-inflammatory cytokine interleukin-18 (IL-18) were investigated on both normal and isolated N-methyl-D-aspartate (NMDA) receptor-mediated field excitatory post synaptic potentials (fEPSP) and on the induction of long-term potentiation (LTP) in the rat dentate gyrus in vitro. Bath perfusion with IL-18 (100 ng/ml) for 20 min prior to high-frequency stimulation had no significant effect on baseline synaptic transmission or paired pulse depression, but did impair the induction of LTP (115.7 +/- 8.8% versus 150.8 +/- 8.1% in vehicle control slices, n=6, P