Bronchopulmonary dysplasia: An update
Bronchopulmonary dysplasia: An update
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DOI：
10.1007/s12098-007-0032-z
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发表时间：
2007-01-01
影响因子：
4.3
通讯作者：
Bhandari, Vineet
中科院分区：
文献类型：
--
作者：
Bhandari, Anita;Bhandari, Vineet
支气管肺发育不良（BPD）是一种与早产相关的慢性肺部疾病，以早期肺损伤为特征。在过去的40年里，BPD的定义、病理和放射学表现以及治疗都发生了重大变化。这种肺部疾病的急性期和晚期的管理继续发展。使用无创通气技术、重组人SOD和CC10以及吸入NO是一些正在研究的新方法。充足的营养对优化肺部生长和修复至关重要。广泛接受的预防病毒感染的做法显著降低了再住院率。然而，患有BPD的婴儿仍然有明显的肺部和神经发育后遗症。揭示基因对BPD的影响将有可能为改进预防和治疗方法铺平道路。
Bronchopulmonary dysplasia (BPD) is a chronic lung disease associated with premature birth and characterized by early lung injury. Over the past 4 decades, there have been significant changes in its definition, pathology and radiological findings as well as management of BPD. Management of the acute phase and later stages of this lung disease continue to evolve. Use of non-invasive ventilatory techniques, recombinant human SOD and CC10 and inhaled NO are some novel approaches that are being studied. Adequate nutrition is vital to optimize lung growth and repair. The widely accepted practice of prophylaxis against viral infections has markedly decreased the rates of rehospitalization. Infants with BPD, however, continue to have significant pulmonary and neurodevelopmental sequelae. Unraveling the genetic contribution to BPD will potentially pave the way to improved preventive and therapeutic approaches.