ANTIBIOTICS PREVENT LIVER-INJURY IN RATS FOLLOWING LONG-TERM EXPOSURE TO ETHANOL
ANTIBIOTICS PREVENT LIVER-INJURY IN RATS FOLLOWING LONG-TERM EXPOSURE TO ETHANOL
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DOI：
10.1016/0016-5085(95)90027-6
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发表时间：
1995-01-01
期刊：
影响因子：
29.4
通讯作者：
THURMAN, RG
中科院分区：
文献类型：
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作者：
ADACHI, Y;MOORE, LE;THURMAN, RG
背景/目的：枯否细胞参与酒精诱导的肝损伤，并在人类酗酒者和大鼠模型中观察到内毒素血症。本研究旨在评价肠道消毒减少细菌内毒素产生对酒精性肝损伤的影响。方法：雄性Wistar大鼠连续灌胃乙醇3周。用多粘菌素B和新霉素对肠道进行灭菌。结果：用抗生素治疗的乙醇喂养大鼠的粪便样本的粪便培养显示几乎没有革兰氏阴性菌的生长。乙醇喂养大鼠血浆中80-90 pg/mL的内毒素水平降低至
Background/Aims: Kupffer's cells participate in alcohol-induced liver injury, and endotoxemia is observed in human alcoholics and in a rat model. This study evaluated the effect of reducing bacterial endotoxin production by intestinal sterilization on alcohol-induced liver injury. Methods: Male Wistar rats were exposed to ethanol continuously for up to 3 weeks via intragastric feeding. The gut was sterilized with polymyxin B and neomycin. Results: Fecal culture of stool samples from ethanol-fed rats treated with antibiotics showed virtually no growth of gram-negative bacteria. Endotoxin levels of 80-90 pg/mL in plasma of ethanol-fed rats were reduced to