Hemodynamic and electrophysiological relationship involved in human face processing: Evidence from a combined fMRI-ERP study
Hemodynamic and electrophysiological relationship involved in human face processing: Evidence from a combined fMRI-ERP study
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DOI：
10.1016/j.bandc.2005.11.004
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发表时间：
2006-03-01
影响因子：
2.5
通讯作者：
Sadato, N
中科院分区：
文献类型：
--
作者：
Iidaka, T;Matsumoto, A;Sadato, N
功能磁共振成像（fMRI）和事件相关电位（ERP）实验在同一组受试者中进行，并采用相同的任务范式来研究脑内血流动力学和电生理反应之间的可能关系。受试者被要求判断视觉上呈现的刺激是脸还是房子，然后按下相应的按钮。功能性MRI分别识别了梭状回外侧和内侧与面部和房屋相关的区域，而ERP在颞枕电极上显示面部刺激的N170负性显著高于房屋刺激。梭状回BOLD信号与ERP参数的相关性分析表明，该信号与被试的N170潜伏期和振幅密切相关。这些相关性可能表明，在面孔/房屋辨别任务中，认知需求和血流动力学反应的变化与N170峰值潜伏期/振幅的变化相耦合。因此，从两种实验模式中获得的空间和时间信息的综合分析可能有助于研究涉及特定认知任务的神经相关。(c) 2005爱思唯尔公司版权所有。
Functional magnetic resonance imaging (fMRI) and event-related potential (ERP) experiments were conducted in the same group of subjects and with an identical task paradigm to investigate a possible relationship between hemodynamic and electrophysiological responses within the brain. The subjects were instructed to judge whether visually presented stimuli were faces or houses and then press the corresponding button. Functional MRI identified face- and house-related regions in the lateral and medial part of the fusiform gyrus, respectively, while ERP showed significantly greater N170 negativity for face than for house stimuli in the temporo-occipital electrodes. Correlation analysis between the BOLD signal in the fusiform gyrus and ERP parameters demonstrated a close relationship between the signal and both latency and amplitude of N170 across the subjects. These correlations may indicate that the variation in cognitive demand and hemodynamic responses during the face/house discrimination task is coupled with the variation of N170 peak latency/amplitude across the subjects. Thus, integrative analysis of spatial and temporal information obtained from the two experimental modalities may help in studying neural correlates involved in a particular cognitive task. (c) 2005 Elsevier Inc. All rights reserved.