Polydopamine-modified nanocrystalline diamond thin films as a platform for bio-sensing applications
Polydopamine-modified nanocrystalline diamond thin films as a platform for bio-sensing applications
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DOI：
10.1016/j.tsf.2012.11.128
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发表时间：
2013-09-30
期刊：
影响因子：
2.1
通讯作者：
Rypacek, Frantisek
中科院分区：
文献类型：
--
作者：
Pop-Georgievski, Ognen;Neykova, Neda;Rypacek, Frantisek
金刚石具有良好的生物相容性和大的电化学电位窗口，因此，它特别适合于生物功能化和生物传感。基于聚多巴胺（PDA）的贻贝式表面化学可以在保持金刚石表面固有性质的同时实现金刚石表面的改性，本文比较研究了在氢（H）和氧（O）封端的纳米金刚石薄膜（NCD）上由多巴胺水溶液聚合/沉积PDA的方法。多巴胺聚合/沉积在温和条件下进行，这导致汇合的PDA层。使用椭圆偏振光谱法对PDA膜在H-和O-终止的NCD衬底上的生长动力学进行了详细的研究。利用X射线光电子能谱、原子力显微镜和水接触角测量仪分别对PDA膜的化学组成、功能基团分布、表面形貌和润湿性进行了表征，结果表明PDA膜可以作为未来生物功能化和/或光学生物传感应用的平台。(c)2012爱思唯尔有限公司版权所有。
Diamond exhibits good biocompatibility and a large electrochemical potential window, and thus, it is particularly suitable for bio-functionalization and bio-sensing. Modification of the diamond surface can be achieved through mussel-inspired surface chemistry based on polydopamine (PDA) while maintaining the intrinsic properties of the surface.We present a comparative study on the polymerization/deposition of PDA from an aqueous solution of dopamine on hydrogen- (H) and oxygen- (O) terminated nanocrystalline diamond films (NCD). The dopamine polymerization/deposition was performed under mild conditions, which resulted in a confluent PDA layer. A detailed investigation of the growth kinetics of the PDA film on H- and O-terminated NCD substrates was performed using spectroscopic ellipsometry. The chemical composition, the functional group distribution, the surface topography and the wetting properties of the adherent PDA films were evaluated using X-ray photoelectron spectroscopy, atomic force microscopy and water contact angle goniometry, respectively.According to the results, a PDA layer can be used as a platform for future bio-functionalization and/or optical bio-sensing applications. (c) 2012 Elsevier B.V. All rights reserved.