Antioxidation and anti-ageing activities of different stereoisomeric astaxanthin in vitro and in vivo
Antioxidation and anti-ageing activities of different stereoisomeric astaxanthin in vitro and in vivo
复制标题
不同立体异构虾青素的体内外抗氧化和抗衰老活性
DOI：
10.1016/j.jff.2016.05.009
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发表时间：
2016-08-01
影响因子：
5.6
通讯作者：
Xiao, Hang
中科院分区：
文献类型：
--
作者：
Liu, Xiaojuan;Luo, Qingxin;Xiao, Hang
Astaxanthin (AST) is a potent antioxidant with different stereoisomers in nature. However, there have been no reports about the functional activities of different stereoisomers so far. In this study, the antioxidant and anti-ageing activities of 3S,3'S (S), 3R,3'R (R), and mixture (M) AST were evaluated in chemical-based assays, cellular antioxidant assays (CAA), and an organism-based model. S AST exhibited the strongest activity in chemical assays and CAA. The median lifespan of Caenorhabditis elegans fed with S, R and M AST was found to increase by 27.61%, 25.25% and 22.69%, respectively. The three stereoisomeric AST did not cause adverse effects on the physiological functions of C. elegans. A decreasing trend of intracellular ROS accumulation caused by AST treatment was accompanied by the prolonged lifespan. Our results provided mechanistic information on the antioxidation and anti ageing activities of different stereoisomeric AST, which is useful for rational utilization of AST in functional food. (C) 2016 Elsevier Ltd. All rights reserved.
