Calcaneal quantitative ultrasound as a determinant of bone health status: what properties of bone does it reflect?
Calcaneal quantitative ultrasound as a determinant of bone health status: what properties of bone does it reflect?
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DOI：
10.7150/ijms.6765
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发表时间：
2013
影响因子：
3.6
通讯作者：
Ima-Nirwana S
中科院分区：
文献类型：
--
作者：
Chin KY;Ima-Nirwana S
定量超声（QUS）已成为一种方便且流行的骨质疏松症筛查工具。本综述旨在提供QUS测量原理的基本信息，并讨论QUS指数反映的骨特性。 QUS 利用设备产生的高频声波来确定人体骨骼健康状况。体外研究表明，QUS 指数与骨矿物质密度 (BMD)、骨微结构和力学参数显着相关。在人类中，QUS 指数也被发现与 BMD 相关。此外，QUS 可以区分有或没有骨折史的受试者并预测未来骨折的风险。总之，QUS 能够反映骨质量，应该用于骨质疏松症的筛查，特别是在普通人群不太容易获得双 X 射线骨密度仪的发展中国家。
Quantitative ultrasound (QUS) has emerged as a convenient and popular screening tool for osteoporosis. This review aimed to provide basic information on the principle of QUS measurement and discuss the properties of bone reflected by QUS indices. QUS employed high frequency sound waves generated by the device to determine bone health status in humans. In vitro studies showed that QUS indices were significantly associated with bone mineral density (BMD), bone microarchitecture and mechanical parameters. In humans, QUS indices were found to be associated with BMD as well. In addition, QUS could discriminate subjects with and without fracture history and predict risk for future fracture. In conclusion, QUS is able to reflect bone quality and should be used in the screening of osteoporosis, especially in developing countries where dual-X-ray absorptiometry devices are less accessible to the general population.