Targeted molecular imaging agents for cellular-scale bimodal imaging
Targeted molecular imaging agents for cellular-scale bimodal imaging
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DOI：
10.1021/bc049904q
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发表时间：
2004-11-01
影响因子：
4.7
通讯作者：
Bornhop, DJ
中科院分区：
文献类型：
--
作者：
Manning, HC;Goebel, T;Bornhop, DJ
分子影像学是一个强大的工具，有能力阐明生化机制和信号的早期发病的疾病。外周苯二氮卓受体（PBR）的过度表达已在多种疾病状态中观察到，包括胶质母细胞瘤、乳腺癌和阿尔茨海默病。因此，PBR可能是一个有吸引力的目标分子成像。在本文中，作者报告了使用混合给药方法和新型PBR靶向镧系元素螯合物分子成像剂对PBR过表达C6胶质母细胞瘤（脑癌）细胞的细胞摄取和多模式（MRI和荧光）成像。
Molecular imaging is a powerful tool that has the ability to elucidate biochemical mechanisms and signal the early onset of disease. Overexpression of the peripheral benzodiazepine receptor (PBR) has been observed in a variety disease states, including glioblastoma, breast cancer, and Alzheimer's disease. Thus, the PBR could be an attractive target for molecular imaging. In this paper, the authors report cellular uptake and multimodal (MRI and fluorescence) imaging of PBR-overexpressing C6 glioblastoma (brain cancer) cells using a cocktail administration approach and a new PBR targeted lanthanide chelate molecular imaging agent.