A pause in nucleus accumbens neuron firing is required to initiate and maintain feeding.
A pause in nucleus accumbens neuron firing is required to initiate and maintain feeding.
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DOI：
10.1523/jneurosci.0197-10.2010
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发表时间：
2010-03-31
期刊：
影响因子：
--
通讯作者：
Fields HL
中科院分区：
文献类型：
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作者：
Krause M;German PW;Taha SA;Fields HL
NAc失活增加了食物摄入，表明NAc神经元对摄食有持续的抑制作用。我们之前描述了NAc神经元在舔蔗糖时暂停的亚群，并提出暂停允许消耗蔗糖。为了验证这一假设，我们首先记录了糖摄入过程中的NAc神经元，然后通过相同的电极进行电刺激。大量NAc壳和核心神经元在蔗糖消耗和局部电刺激突然中断舔食过程中受到抑制。NAc有效刺激部位比无效刺激部位更靠前。在低刺激强度下，舔舐在刺激抵消后立即恢复。从NAc神经元抑制开始到舔舐恢复的潜伏期（~460 ms）与电刺激抵消后的潜伏期（~440 ms）非常相似。这些结果直接支持了一个假设，即NAc神经元的一个重要亚群抑制美味食物的消耗，并且需要暂停它们的激活来启动和维持消耗。
NAc inactivation increases food intake, indicating that NAc neurons exert ongoing inhibition of feeding. We previously described a subpopulation of NAc neurons that pause during sucrose licking and proposed that the pause permits consumption. We tested this hypothesis by first recording NAc neurons during sucrose consumption, and then electrically stimulating through the same electrodes. A large proportion of NAc shell and core neurons were inhibited during sucrose consumption and local electrical stimulation abruptly interrupted licking. Effective stimulation sites were more anterior than ineffective sites in NAc. At low stimulus intensities, licking resumed immediately upon stimulation offset. The latency to lick resumption from NAc neuron inhibition onset (~460 ms) was very similar to that following electrical stimulation offset (~440 ms). These results directly support the hypothesis that a significant subpopulation of NAc neurons inhibit palatable food consumption and that a pause in their firing is required to initiate and maintain consumption.