Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice
Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice
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DOI：
10.1016/j.bbrc.2008.10.156
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发表时间：
2008-12-26
影响因子：
3.1
通讯作者：
Ohta, Shigeo
中科院分区：
文献类型：
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作者：
Ohsawa, Ikuroh;Nishimaki, Kiyomi;Ohta, Shigeo
氧化应激与动脉粥样硬化形成有关;然而，大多数饮食抗氧化剂的临床试验未能显示预防动脉粥样硬化疾病的显著成功。我们已经发现，氢（二氢; H-2）作为一种有效的抗氧化剂，以减少氧化应激[I]。Ohsawa，M.石川，K.高桥，M. Watanabe，K Nishimaki，K Yamagata，K Katanabe，Y. Katayama，S，Asoh，S. Ohta，Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals，Nat.Med.13（2007）688-694]。在这里，我们调查是否饮用H-2-溶解的水在饱和水平（H-2-水）随意预防动脉粥样硬化使用载脂蛋白E基因敲除小鼠（apoE（-/-）），动脉粥样硬化的自发发展的模型。ApoE（-/-）小鼠从2月龄至6月龄在整个期间自由饮用H-2水。根据主动脉切片的油红O染色系列判断，随意饮用H2水可显著减少动脉粥样硬化病变（p = 0.0069）。降低主动脉氧化应激水平。证实了巨噬细胞在动脉粥样硬化病变中的积聚。因此，饮用溶解有H-2的水具有预防动脉硬化的潜力。(C)2008年爱思唯尔公司All rights reserved.
Oxidative stress is implicated in atherogenesis; however most clinical trials with dietary antioxidants failed to show marked Success in preventing atherosclerotic diseases. We have found that hydrogen (dihydrogen; H-2) acts as an effective antioxidant to reduce oxidative stress [I. Ohsawa, M. Ishikawa, K. Takahashi, M. Watanabe, K Nishimaki, K Yamagata, K Katsura, Y. Katayama, S, Asoh, S. Ohta, Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals, Nat. Med. 13 (2007) 688-694]. Here, we investigated whether drinking H-2-dissolved water at a saturated level (H-2-Water) ad libitum prevents arteriosclerosis using an apolipoprotein E knockout mouse (apoE(-/-)), a model of the spontaneous development of atherosclerosis. ApoE(-/-) mice drank H-2-water ad libitum from 2 to 6 month old throughout the whole period. Atherosclerotic lesions were significantly reduced by ad libitum drinking of H-2-water (p = 0.0069) as Judged by Oil-Red-O staining series of sections of aorta. The oxidative stress level Of aorta was decreased. Accumulation of macrophages in atherosclerotic lesions was confirmed. Thus, consumption of H-2-dissolved Water has the potential to prevent arteriosclerosis. (C) 2008 Elsevier Inc. All rights reserved.