Multiple parietal-frontal pathways mediate grasping in macaque monkeys.
Multiple parietal-frontal pathways mediate grasping in macaque monkeys.
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DOI：
10.1523/jneurosci.1777-11.2011
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发表时间：
2011-08-10
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影响因子：
--
通讯作者：
Kaas JH
中科院分区：
文献类型：
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作者：
Gharbawie OA;Stepniewska I;Qi H;Kaas JH
介导灵长类抓握的顶叶-额叶通路的节点位于前顶叶内区 (AIP) 和腹侧前运动皮层 (PMv)。然而，手的多种体感和运动表征（分别在顶叶和额叶皮层）表明其他途径仍未实现。我们在猕猴身上探索了这种可能性，通过将逆行示踪剂注入 M1、PMv 和区域 2 中确定的长电刺激抓握区域。 M1 抓握区与其他额叶皮层运动区域紧密相连。其余连接源自体感区域 3a 和 S2/PV，以及顶内沟 (IPS) 的内侧岸和眼底。 PMv 抓握区也与额叶皮层运动区域紧密相连，尽管程度比 M1 抓握区要小。其余连接源自 S2/PV 区域以及顶下叶的各个方面，例如 PF、PFG、AIP 和 IPS 尖端。区域 2 的抓握区域与体感区域 3b、1 和 S2/PV 的手部表征紧密相连。其余的连接与区域 3a 和 5 以及 IPS 的内侧银行和眼底。与额叶皮层的连接相对较弱，集中在尾部 M1。因此，三个抓握区可能是平行顶叶-额叶通路的节点。每个途径的不同起始点和终止点表明不同的功能专业化。这些顶叶通路之间的直接和间接连接可能会协调它们各自的功能以实现准确的掌握。
The nodes of a parietal-frontal pathway that mediates grasping in primates are in anterior intraparietal area (AIP) and ventral premotor cortex (PMv). Nevertheless, multiple somatosensory and motor representations of the hand, respectively in parietal and frontal cortex, suggest that additional pathways remain unrealized. We explored this possibility in macaque monkeys by injecting retrograde tracers into grasp zones identified in M1, PMv, and area 2 with long train electrical stimulation. The M1 grasp zone was densely connected with other frontal cortex motor regions. The remainder of the connections originated from somatosensory areas 3a and S2/PV, and from the medial bank and fundus of the intraparietal sulcus (IPS). The PMv grasp zone was also densely connected with frontal cortex motor regions, albeit to a lesser extent than the M1 grasp zone. The remainder of the connections originated from areas S2/PV and aspects of the inferior parietal lobe such as PF, PFG, AIP, and the tip of the IPS. The area 2 grasp zone was densely connected with the hand representations of somatosensory areas 3b, 1, and S2/PV. The remainder of the connections was with areas 3a and 5 and the medial bank and fundus of the IPS. Connections with frontal cortex were relatively weak and concentrated in caudal M1. Thus, the three grasp zones may be nodes of parallel parietal-frontal pathways. Differential points of origin and termination of each pathway suggest varying functional specializations. Direct and indirect connections between those parietal-frontal pathways likely coordinate their respective functions into an accurate grasp.