Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine level reduced by scopolamine, hypoxia and ischemia in the rats and mongolian gerbils.
Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine level reduced by scopolamine, hypoxia and ischemia in the rats and mongolian gerbils.
复制标题
盐酸比非美烷 (MCI-2016) 对东莨菪碱降低乙酰胆碱水平、大鼠和沙鼠缺氧和缺血的影响。
DOI：
10.1254/jjp.38.375
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
I. Yanagiya
中科院分区：
文献类型：
--
作者：
K. Saito;S. Honda;A. Tobe;I. Yanagiya
研究盐酸双星黑烷（MCI-2016）对大鼠和蒙古沙鼠大脑皮层和海马中乙酰胆碱（ACh）水平的影响。在正常大鼠中，MCI-2016 （30 mg/kg, i.p）轻微增加大脑皮层ACh含量。东莨菪碱（1 mg/kg, ig）或缺氧（95% N2 +5% O2, 9 min）均能降低大鼠乙酰胆碱水平，MCI-2016预处理能减弱大鼠乙酰胆碱水平的下降。结扎双侧颈动脉后，蒙古沙鼠脑内乙酰胆碱含量明显降低。在这种情况下，MCI-2016也减弱了ACh水平的下降。这些结果表明，MCI-2016对东莨菪碱、缺氧或缺血治疗动物的行为障碍的改善可能至少部分归因于脑内乙酰胆碱水平下降的改善。
Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine (ACh) level in the cerebral cortex and hippocampus of rats and Mongolian gerbils were examined. In normal rats, MCI-2016 (30 mg/kg, i.p.) slightly increased ACh content in the cerebral cortex. Scopolamine (1 mg/kg, i.p.) or hypoxia (95% N2 +5% O2, 9 min) decreased ACh level and pretreatment of MCI-2016 attenuated the decrement of ACh level in the rats. ACh level in the brain of Mongolian gerbils was significantly decreased following ligation of bilateral carotid arteries. In this case, MCI-2016 also attenuated the decrement of ACh level. These results suggest that improvement by MCI-2016 of behavioral impairment observed in the animals treated with scopolamine, hypoxia or ischemia may be, at least partly, attributed to the amelioration of decreased ACh level in the brain.