SELECTIVE PREFRONTAL CORTICAL PROJECTIONS TO THE REGION OF THE LOCUS COERULEUS AND RAPHE NUCLEI IN THE RHESUS-MONKEY
SELECTIVE PREFRONTAL CORTICAL PROJECTIONS TO THE REGION OF THE LOCUS COERULEUS AND RAPHE NUCLEI IN THE RHESUS-MONKEY
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DOI：
10.1016/0006-8993(84)90351-2
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发表时间：
1984-01-01
期刊：
影响因子：
2.9
通讯作者：
GOLDMANRAKIC, PS
中科院分区：
文献类型：
--
作者：
ARNSTEN, AFT;GOLDMANRAKIC, PS
应用顺行标记技术，对恒河猴下行皮质投射到去甲肾上腺素能蓝斑（LC）和肾上腺素能中缝背核和中央上级核的投射进行了分析。将HRP颗粒或氚化亮氨酸注射到7个皮质区域中的1个：背外侧前额叶皮质;背内侧前额叶皮质;眶前额叶皮质;顶叶联合皮质;体感皮质;颞下回前部;和颞下回后部。顺行标记的纤维被发现在LC和中缝核和邻近的背外侧和背内侧前额叶皮质注射后。终末标记在LC的吻侧水平，特别是在该地区直接内侧的核。标记的纤维不能超出LC的尾侧水平。对侧LC和中缝核的投射与同侧相似，但密度较低。注射到皮质区以外的背侧前额叶皮质导致顺行标记的脑桥核或金字塔，但不是LC/中缝区域。这些数据，结合在大鼠中的研究，表明背侧前额叶皮质可能是唯一的皮质区有直接影响的LC和中缝核和次要影响的单胺能神经支配的大面积的大脑皮层。
Descending cortical projection to the region of the noradrenergic locus coeruleus (LC) and the serotonergic dorsal and central superior raphe nuclei were analyzed in the rhesus monkey using anterograde labeling techniques. HRP pellets or tritiated leucine were injected into 1 of 7 cortical areas: the dorsolateral prefrontal cortex; the dorsomedial prefrontal cortex; the orbital prefrontal cortex; the parietal association cortex; somatosensory cortex; the anterior portion of the inferior temporal gyrus; and the posterior portion of the inferior temporal gyrus. Anterogradely labeled fibers were found in and adjacent to the LC and raphe nuclei only following the dorsolateral and dorsomedial prefrontal cortical injections. Terminal labeling was densest at rostral levels of the LC, particularly in the area directly medial to the nucleus. Labeled fibers could not be followed beyond caudal levels of the LC. The projections to the contralateral LC and raphe nuclei were similar to, but less dense than that to the ipsilateral region. Injections into cortical areas other than the dorsal prefrontal cortex resulted in anterograde labeling of the pontine nuclei or pyramids, but not the LC/raphe region. These data, in conjunction with studies in the rat, suggest that the dorsal prefrontal cortex may be the only cortical area to have direct influence on the LC and raphe nuclei and secondary influence on the monoaminergic innervation of large areas of cerebral cortex.