Antifungal Activity of Alkaloids Against Candida albicans.
Antifungal Activity of Alkaloids Against Candida albicans.
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DOI：
10.1080/19424396.2016.12221046
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发表时间：
2016-08
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影响因子：
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通讯作者：
J. Noguti;M. Rajinia;B. Zancopé;M. C. S. Marquezin;D. Seleem;V. Pardi;R. Murata
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文献类型：
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作者：
J. Noguti;M. Rajinia;B. Zancopé;M. C. S. Marquezin;D. Seleem;V. Pardi;R. Murata
白色念珠菌是口腔中的一种病原体，通常是无害的机会性感染。天然产物已被用于开发几种药物，主要是抗癌和抗感染药物。其中，生物碱因其药用特性而被研究。在本研究中，我们检测了它们对白色念珠菌的体外抗真菌活性。在本研究的生物碱中，盐酸小檗碱对白色念珠菌的活性最好。
Candida albicans is a pathogen in the mouth responsible for opportunistic infections that are usually harmless. Natural products have been used to develop several drugs, mostly anticancer and anti-infective agents. Among these, alkaloids have been studied for their medicinal properties. In this study, we examined their antifungal activity against C. albicans in vitro. Among the alkaloids studied in this work, berberine hydrochloride showed the best activity against C. albicans.