LONGITUDINAL-STUDIES OF ESTROUS CYCLICITY IN AGING C57BL/6J MICE .2. CESSATION OF CYCLICITY AND THE DURATION OF PERSISTENT VAGINAL CORNIFICATION
LONGITUDINAL-STUDIES OF ESTROUS CYCLICITY IN AGING C57BL/6J MICE .2. CESSATION OF CYCLICITY AND THE DURATION OF PERSISTENT VAGINAL CORNIFICATION
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DOI：
10.1095/biolreprod31.3.446
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发表时间：
1984-01-01
影响因子：
3.6
通讯作者：
FINCH, CE
中科院分区：
文献类型：
--
作者：
FELICIO, LS;NELSON, JF;FINCH, CE
年龄的发病无周期性和持续性阴道角化（PVC），主要的周期后无排卵条件的持续时间，测定了5个队列的处女小鼠交错在6年的时间间隔。停止周期性的平均年龄在队列中差异显着，范围从11至16个月。75%的小鼠在停止周期后进入PVC，其余小鼠直接进入持续性间情状态。PVC的持续时间平均为2 ~ 4个月。个体间差异显著，与非周期性发作的年龄呈负相关。因此，与周期性停止相关的方差约为与PVC停止相关的方差的4倍。控制排卵失败和PVC停止的因素可能不同。
Age of onset of acyclicity and the duration of persistent vaginal cornification (PVC), the predominant postcyclic anovulatory condition, were measured in 5 cohorts of virgin mice staggered across a 6-yr interval. The average age of cessation of cyclicity varied significantly among cohorts, ranging from 11 to 16 mo. of age; 75% of the mice entered PVC after ceasing to cycle, the remainder entered directly into a persistent diestrous condition. The duration of PVC, which averaged between 2 and 4 mo. varied markedly among individuals and was inversely related to the age of onset of acyclicity. Consequently, the variance associated with the cessation of cyclicity was about 4-fold greater than that associated with the cessation of PVC. The factors governing ovulatory failure and PVC cessation may differ.