Efficient asymmetric synthesis of ABT-594; a potent, orally effective analgesic
Efficient asymmetric synthesis of ABT-594; a potent, orally effective analgesic
复制标题
DOI：
10.1016/s0957-4166(98)00291-2
复制
发表时间：
1998-08-21
影响因子：
--
通讯作者：
King, SA
中科院分区：
文献类型：
--
作者：
Lynch, JK;Holladay, MW;King, SA
以d -天冬氨酸二苯酯为原料，经三步反应得到关键中间体t-丁氧羰基保护的(2R)-氮基二醇，产率为44%，ee为99%。1998爱思唯尔科学有限公司版权所有。
A concise asymmetric synthesis of (R)-2-chloro-5-(2-azetidinylmethoxy)pyridine (ABT-594) is presented in which the key intermediate t-butoxycarbonyl protected (2R)-azetidinylalcohol is obtained in three steps from the dibenzyl ester of D-aspartic acid in 44% yield and >99% ee. (C) 1998 Elsevier Science Ltd. All rights reserved.