Disintegrins from snake venoms and their applications in cancer research and therapy.
Disintegrins from snake venoms and their applications in cancer research and therapy.
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DOI：
10.2174/1389203716666150515125002
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发表时间：
2015
影响因子：
2.8
通讯作者：
de Souza Castro M
中科院分区：
文献类型：
--
作者：
Arruda Macêdo JK;Fox JW;de Souza Castro M
整合素调节癌症病理学和肿瘤细胞发育中的多种功能，并有助于重要过程，如细胞形状、存活、增殖、转录、血管生成、迁移和侵袭。许多蛇毒蛋白具有与整合素相互作用的能力。其中包括去整合素，这是一个小的，非酶的，富含半胱氨酸的蛋白质家族，存在于许多蛇类的毒液中。毒液蛋白可能在癌症治疗的新治疗线索方面具有潜在的作用。去整合素可以靶向特定的整合素，因此可以想象，它们可以干扰参与癌变、肿瘤生长、侵袭和迁移的重要过程。在这里，我们提出了一个调查的研究，涉及使用蛇毒去整合素的癌症检测和治疗。这篇综述的目的是强调整合素与癌症的关系，并举例说明某些去整合素如何检测和影响与癌症相关的生物学过程。这反过来将说明这些分子在癌症研究中的巨大潜力。此外，我们还概述了几种新的方法正在创建，以解决与肽类药物的临床应用，如不稳定性，免疫原性和可用性通常相关的问题。
Integrins regulate diverse functions in cancer pathology and in tumor cell development and contribute to important processes such as cell shape, survival, proliferation, transcription, angiogenesis, migration, and invasion. A number of snake venom proteins have the ability to interact with integrins. Among these are the disintegrins, a family of small, non-enzymatic, and cysteine-rich proteins found in the venom of numerous snake families. The venom proteins may have a potential role in terms of novel therapeutic leads for cancer treatment. Disintegrin can target specific integrins and as such it is conceivable that they could interfere in important processes involved in carcinogenesis, tumor growth, invasion and migration. Herein we present a survey of studies involving the use of snake venom disintegrins for cancer detection and treatment. The aim of this review is to highlight the relationship of integrins with cancer and to present examples as to how certain disintegrins can detect and affect biological processes related to cancer. This in turn will illustrate the great potential of these molecules for cancer research. Furthermore, we also outline several new approaches being created to address problems commonly associated with the clinical application of peptide-based drugs such as instability, immunogenicity, and availability.