EphrinB3 regulates cell proliferation and survival in adult neurogenesis
EphrinB3 regulates cell proliferation and survival in adult neurogenesis
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DOI：
10.1016/j.mcn.2006.01.002
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发表时间：
2006-04-01
影响因子：
3.5
通讯作者：
Liebl, DJ
中科院分区：
文献类型：
--
作者：
Ricard, J;Salinas, J;Liebl, DJ
肾上腺素及其受体之间的相互作用参与了中枢神经系统发育的许多过程。在成人中，肾上腺素和Eph受体被认为与控制细胞增殖和神经母细胞迁移有关，尽管没有直接证据表明ewitinB3在这些功能中发挥作用。此外，Eph受体的激活已被证明调节在细胞周期控制和细胞死亡中重要的转导通路。我们的研究表明，在成人室下区(SVZ)，ewitinB3有助于控制细胞的增殖和存活。EwitinB3(-/-)小鼠表现出显著的分裂增加，细胞沿着侧脑室，并改变了参与细胞周期调节的蛋白质的表达。功能获得性方法通过将可溶的ewitinB3-Fc分子注入ewitinB3(-/-)Call将细胞增殖抑制到野生型水平。同时，当ewitinB3(-/-)小鼠的SVZ中有更多的细胞死亡时，ewitinB3也调节细胞的存活。综上所述，我们的研究结果表明，在成人室下区，ewitinB3负向调节细胞周期进程和细胞凋亡。(C)2006 Elsevier Inc.保留所有权利。
Interactions between ephrins and their receptors have been implicated in many processes during central nervous system development. In the adult, ephrins and Eph receptors have been implicated in controlling cell proliferation and neuroblast migration, although there is no direct evidence for the role of ephrinB3 in these functions. In addition, activation of Eph receptors has been shown to regulate transduction pathways important in cell cycle control as well as cell death. We show that ephrinB3 contributes to the control of cell proliferation and survival in the adult subventricular zone (SVZ). EphrinB3(-/-) mice exhibit a significant increase in dividing, cells along the lateral ventricle, and altered expression of proteins involved in cell cycle regulation. Gain-of-function approach by infusing soluble ephrinB3-Fc molecules in ephrinB3(-/-) call suppress cell proliferation to wild type levels. At the same time, ephrinB3 also regulates cell survival as greater numbers of cells die in the SVZ of ephrinB3(-/-) mice. Together, our results suggest that ephrinB3 negatively regulates cell cycle progression and cell apoptosis in the adult subventricular zone. (c) 2006 Elsevier Inc. All rights reserved.