Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family.
Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family.
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DOI：
10.1016/s0021-9258(19)49823-2
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发表时间：
1992-06
期刊：
影响因子：
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通讯作者：
H. Vos;S. Devarayalu;Y. de Vries;P. Bornstein
中科院分区：
文献类型：
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作者：
H. Vos;S. Devarayalu;Y. de Vries;P. Bornstein
血小板反应蛋白基因家族的第三个成员（Thbs 3）已在小鼠中部分表征。在小鼠和人类中，Thbs 3/THBS 3基因位于Muc 1/MUC 1（episialin）基因的上游;不到3个腺苷酸酶将一个基因的多聚腺苷酸化信号与另一个基因的转录起始分开。Thbs 3中的可用编码序列显示出与Thbs 1和Thbs 2的高度氨基酸序列同一性（在外显子15和16中分别为58%和59%），但是Thbs 3的外显子/内含子组织似乎比先前描述的两个家族成员的组织更不同。Thbs 3 mRNA的较短长度（3.5千碱基）很大程度上归因于较短的3 '非翻译区。Thbs 3基因在小鼠组织中以独特的模式表达，在肺中表达水平最高。这种模式表明Thbs 3基因的翻译产物具有独特的功能。
A third member of the thrombospondin gene family (Thbs3) has been partially characterized in the mouse. In both the mouse and humans, the Thbs3/THBS3 gene is located immediately upstream from the Muc1/MUC1 (episialin) gene; less than 3 kilobases separate the polyadenylation signal of one gene from the start of transcription of the other. The available coding sequence in Thbs3 shows a high degree of amino acid sequence identity to Thbs1 and Thbs2 (58 and 59%, respectively, in exons 15 and 16), but the exon/intron organization of Thbs3 appears to be more disparate than that of the two previously described members of the family. The shorter length of the Thbs3 mRNA (3.5 kilobases) can be attributed largely to a shorter 3'-untranslated region. The Thbs3 gene is expressed in a distinctive pattern in mouse tissues, with the highest level of expression in lung. This pattern suggests a unique function for the translation product of the Thbs3 gene.