Genetic polymorphisms of cytochrome P450 2A6 in a case-control study on lung cancer in a French population
Genetic polymorphisms of cytochrome P450 2A6 in a case-control study on lung cancer in a French population
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DOI：
10.1097/00008571-200102000-00005
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发表时间：
2001-02-01
期刊：
影响因子：
--
通讯作者：
Stücker, I
中科院分区：
文献类型：
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作者：
Loriot, MA;Rebuissou, S;Stücker, I
细胞色素P450 2A6 （CYP2A6）参与尼古丁的c -氧化和烟草亚硝胺的代谢激活。最近的数据表明，CYP2A6基因多态性可能在烟草依赖和消费以及肺癌风险中起作用，然而，先前发表的研究基于一种基因分型方法，高估了缺失等位基因的频率，导致对CYP2A6基因型的错误分类。在本研究中，我们对244名肺癌患者和250名对照者的CYP2A6（野生型等位基因CYP2A6*1）和两个缺失等位基因的DNA进行了基因分型：CYP2A6*2和CYP2A6*4，后者对应于基因的缺失)使用更具体的程序。在该高加索人群中，我们没有发现尼古丁代谢基因受损与吸烟之间的关系，也没有发现CYP2A6等位基因缺陷导致肺癌风险的改变（优势比= 1.1,95%置信区间= 0.7-1.9）。中国生物医学工程学报（英文版）。
Cytochrome P450 2A6 (CYP2A6) is involved in the C-oxidation of nicotine and in the metabolic activation of tobacco nitrosamines. Recent data have suggested that CYP2A6 genetic polymorphisms might play a role in tobacco dependence and consumption as well as in lung cancer risk, However, the previously published studies were based on a genotyping method that overestimated the frequencies of deficient alleles, leading to misclassification for the CYP2A6 genotype, In this study, we genotyped DNA from 244 lung cancer patients and from 250 control subjects for CYP2A6 (wild-type allele CYP2A6*1, and two deficient alleles: CYP2A6*2, and CYP2A6*4, the latter corresponding to a deletion of the gene) using a more specific procedure. In this Caucasian population, we found neither a relation between genetically impaired nicotine metabolism and cigarette consumption, nor any modification of lung cancer risk related to the presence of defective CYP2A6 alleles (odds ratio = 1.1, 95% confidence interval = 0.7-1.9). Pharmacogenetics 11:39-44 (C) 2001 Lippincott Williams & Wilkins.