Pore-Forming Toxins During Bacterial Infection: Molecular Mechanisms and Potential Therapeutic Targets.
Pore-Forming Toxins During Bacterial Infection: Molecular Mechanisms and Potential Therapeutic Targets.
复制标题
细菌感染过程中孔形成毒素：分子机制和潜在的治疗靶标。
DOI：
10.2147/dddt.s322393
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Sun S
中科院分区：
文献类型：
--
作者：
Hu H;Liu M;Sun S
细菌感染主要通过抗生素治疗，而抗生素耐药性正在成为对我们健康的日益严重的威胁。成孔毒素（PFT）是由许多致病性细菌菌株分泌的毒力因子，在急性和慢性感染中均存在。它们是特殊的膜靶向蛋白，通过在细胞膜上形成孔来发挥毒性作用。最近的研究已经阐明了PFTs的结构及其致病的详细分子机制。在这里，我们讨论了最近的研究结果，强调了两种类型的PFT，α-PFT和β-PFT的调节机制和重要作用，在介导细菌的毒力，以及靶向PFT的抗菌治疗的治疗潜力。基于PFT的治疗策略具有高度特异性，可以缓解抗生素耐药性增加的问题。
Bacterial infections are predominantly treated with antibiotics, and resistance to antibiotics is becoming an increasing threat to our health. Pore-forming toxins (PFTs) are virulence factors secreted by many pathogenic bacterial strains, both in acute and chronic infections. They are special membrane-targeting proteins that exert toxic effects by forming pores in the cell membrane. Recent studies have elucidated the structure of PFTs and the detailed molecular mechanisms of their pathogenicity. Here, we discuss recent findings that highlight the regulatory mechanisms and important roles of two types of PFTs, α-PFTs and β-PFTs, in mediating the virulence of bacteria, and the therapeutic potential of targeting PFTs for antibacterial treatment. Therapeutic strategies based on PFTs are highly specific and may alleviate the issue of increasing resistance to antibiotics.