Caloric Restriction and Toxicity
Caloric Restriction and Toxicity
复制标题
热量限制和毒性
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
B. Lyn
中科院分区：
文献类型：
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作者：
R. Hart;K. Keenan;A. Turturro;K. Abdo;J. Leakey;B. Lyn
热量限制和毒性。 Hart, R. W.、Keenan, K.、Turturro, A.、Abdo, K. M. Leakey, J.、Lyn-Cook, B. (1995)。芬达姆。应用。毒性。 25、184-195。
热量摄入对自发和诱发疾病发病率和程度的调节作用是众所周知的，但这些作用在解释测试数据中的重要性直到最近才被认识到。相对于热量摄入对常见肿瘤生存率和背景发病率的影响尤其如此。为了增强正在进行的慢性毒性测试的动物的健康和生存，有人建议此类测试应限制食物消耗。尽管这种限制将导致测试动物的存活率增加，但它也可能通过改变药物代谢和疾病进展来影响毒性的表达。本次研讨会的重点是毒性试验中控制饮食摄入量（饮食控制）的必要性，以及如果确实存在这种需要，饮食应该关注到什么水平的摄入量（热量限制）。
Caloric Restriction and Toxicity. Hart, R. W., Keenan, K., Turturro, A., Abdo, K. M. Leakey, J., Lyn-Cook, B. (1995). Fundam. Appl. Toxicol. 25, 184-195.
The modulatory effects of caloric intake on the rate and extent of both spontaneous and induced disease incidence is well known, but the significance of these effects in the interpretation of testing data has only recently become appreciated. This is especially true relative to the impact of caloric intake on both survival and background incidence for common tumors. In order to enhance the health and survival of animals ongoing chronic toxicity testing it has been suggested that such tests should restrict food consumption. Although this restriction will result in increasing survival of the test animals, it may also effect the expression of toxicity by altering agent metabolism and disease progression. Focus in this symposium is on the necessity to control dietary consumption in toxicity tests (dietary control), and if such a need does exist to what level of consumption should be diet be focused (caloric restriction).