THE RELATIONSHIP OF WHITE CELL COUNT, PLATELET COUNT, AND HEMATOCRIT TO CIGARETTE-SMOKING IN ADOLESCENTS - THE OSLO YOUTH STUDY
THE RELATIONSHIP OF WHITE CELL COUNT, PLATELET COUNT, AND HEMATOCRIT TO CIGARETTE-SMOKING IN ADOLESCENTS - THE OSLO YOUTH STUDY
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DOI：
10.1161/01.cir.72.5.971
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发表时间：
1985-01-01
期刊：
影响因子：
37.8
通讯作者：
THEODORSEN, L
中科院分区：
文献类型：
--
作者：
TELL, GS;GRIMM, RH;THEODORSEN, L
本文报道了挪威青少年人群中吸烟、白细胞计数（WBC）、血小板计数（PC）和红细胞压积之间的关系。作为奥斯陆青年研究的一部分，获得了439名14至16岁青少年的数据，该研究是对青少年心血管疾病和癌症的风险因素和行为的调查。协方差分析，控制身高、体重、年龄、性成熟、高密度脂蛋白（HDL）胆固醇和红细胞压积显示，男性和女性经常吸烟者（每周至少吸烟一次的人）的平均白细胞明显较高。经常吸烟的男性的pc也明显高于不吸烟者，经常吸烟的女性的pc也高于每月吸烟少于一次的年轻女性。在调整身高、体重、年龄、性成熟和高密度脂蛋白胆固醇后，经常吸烟的男性红细胞压积显著降低，而经常吸烟的女性红细胞压积值高于不吸烟者或偶尔吸烟者。本研究结果显示，在较晚开始吸烟的青少年中，白细胞计数和白细胞计数均有所增加。这表明，在吸烟者中观察到的白细胞计数增加不太可能是由于长期吸烟引起的慢性疾病状况。
This article reports on the relationship between cigarette smoking, white blood cell count (WBC), platelet count (PC), and hematocrit in a Norwegian adolescent population. Data were obtained on 439 youths, 14 to 16 years old, as part of the Oslo Youth Study, an investigation of risk factors and behaviors for cardiovascular disease and cancer among adolescents. Analyses of covariance, controlling for height, weight, age, sexual maturation, high-density lipoprotein (HDL) cholesterol, and hematocrit revealed that both male and female regular smokers (those reporting smoking at least once a week) had significantly higher mean WBCs. Male regular smokers also had significantly higher PCs than nonsmokers, and female regular smokers had higher PCs than young women who smoked less often than once a month. Hematocrit, after adjustment for height, weight, age, sexual maturation, and HDL cholesterol, was significantly lower in male regular smokers, while female regular smokers had higher hematocrit values than nonsmokers or occasional smokers. Results of this study show that WBC and PC were increased in adolescents who started smoking relatively recently. This indicates that the increase in white cell count observed in smokers is unlikely to be due to a long-standing smoking-induced chronic disease condition.