T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens
T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens
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DOI：
10.1038/ni806
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发表时间：
2002-07-01
影响因子：
30.5
通讯作者：
Selin, LK
中科院分区：
文献类型：
--
作者：
Brehm, MA;Pinto, AK;Selin, LK
我们在这里表明，异源病毒之间的T细胞交叉反应性通过两种机制影响病毒特异性CD 8（+）T细胞的免疫优势。首先，对交叉反应性表位特异的T细胞主导对病毒感染的急性反应;其次，在记忆池内，对交叉反应性表位特异的T细胞被维持，而对非交叉反应性表位特异的T细胞被选择性地丢失。这些发现表明了一种免疫学范式，其中病毒感染塑造了可用的T细胞库，导致随后的病毒感染引起的初级和记忆CD 8（+）T细胞应答的层次结构发生改变。因此，免疫优势是宿主先前暴露于不相关病原体的功能，这可能对保护性免疫和免疫病理学产生影响。
We show here that T cell cross-reactivity between heterologous viruses influences the immuno-dominance of virus-specific CD8(+) T cells by two mechanisms. First, T cells specific for cross-reactive epitopes dominate acute responses to viral infections; second, within the memory pool, T cells specific for cross-reactive epitopes are maintained while those specific for non-cross-reactive epitopes are selectively lost. These findings suggest an immunological paradigm in which viral infections shape the available T cell repertoire, causing alterations in the hierarchies of both the primary and memory CD8(+) T cell responses elicited by subsequent viral infections. Thus, immunodominance is a function of the host's previous exposure to unrelated pathogens, and this may have an impact on protective immunity and immunopathology.