Correlation of Snail expression with histological grade and lymph node status in breast carcinomas
Correlation of Snail expression with histological grade and lymph node status in breast carcinomas
复制标题
DOI：
10.1038/sj.onc.1205416
复制
发表时间：
2002-05-09
期刊：
影响因子：
8
通讯作者：
Nieto, MA
中科院分区：
文献类型：
--
作者：
Blanco, MJ;Moreno-Bueno, G;Nieto, MA
Snail是一种锌指转录因子，通过直接抑制E-cadherin的表达来触发上皮-间质转化（EMT）。蜗牛是胚胎发育过程中胚层和神经嵴形成所必需的，最近被认为与肿瘤进展相关的EMT有关。在一系列的人类乳腺癌，我们分析了表达的蜗牛和分子的E-钙粘蛋白/连环蛋白复合物。我们还将这些数据与肿瘤的病理特征相关联。我们发现Snail表达与肿瘤的分化程度呈负相关，并且它在所有分析的淋巴结转移的浸润性导管癌（IDC）中表达。此外，Snail在一些具有阴性淋巴结状态的去分化肿瘤中表达。考虑到Snail参与上皮细胞中侵袭性和迁移性表型的诱导，这些结果表明它也参与乳腺导管肿瘤的进展，其中它可以另外作为转移潜力的标志物。
Snail is a zinc finger transcription factor that triggers the epithelial-mesenchymal transition (EMT) by directly repressing E-cadherin expression. Snail is required for mesoderm and neural crest formation during embryonic development and has recently been implicated in the EMT associated with tumour progression. In a series of human breast carcinomas, we have analysed the expression of Snail and that of molecules of the E-cadherin/catenin complexes. We have also correlated these data with the pathological features of the tumours. We show that Snail expression inversely correlates with the grade of differentiation of the tumours and that it is expressed in all the infiltrating ductal carcinomas (IDC) presenting lymph node metastases that were analysed. In addition, Snail is expressed in some dedifferentiated tumours with a negative nodal status. Considering that Snail is involved in the induction of the invasive and migratory phenotype in epithelial cells, these results indicate that it is also involved in the progression of breast ductal tumours, where it could additionally serve as a marker of the metastatic potential.