Transfer characteristics of a thermosensory synapse in Caenorhabditis elegans
Transfer characteristics of a thermosensory synapse in Caenorhabditis elegans
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DOI：
10.1073/pnas.1106617108
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发表时间：
2011-06-07
影响因子：
11.1
通讯作者：
Sternberg, Paul W.
中科院分区：
文献类型：
--
作者：
Narayan, Anusha;Laurent, Gilles;Sternberg, Paul W.
秀丽隐杆线虫是一种用于神经回路分析的紧凑、有吸引力的系统。要理解神经计算的功能动力学，需要进行生理学分析。我们通过结合对目标神经元的光刺激和电生理记录，对线虫的中央突触进行了转移的表征。我们发现AFD和AIY之间的突触呈现兴奋性、紧张性和渐进性释放，这是温度趋化回路的第一阶段。我们测量了输入输出曲线的线性范围，并估计静态突触增益为0.056(
Caenorhabditis elegans is a compact, attractive system for neural circuit analysis. An understanding of the functional dynamics of neural computation requires physiological analyses. We undertook the characterization of transfer at a central synapse in C. elegans by combining optical stimulation of targeted neurons with electrophysiological recordings. We show that the synapse between AFD and AIY, the first stage in the thermotactic circuit, exhibits excitatory, tonic, and graded release. We measured the linear range of the input-output curve and estimate the static synaptic gain as 0.056 (