Brain imaging in the assessment for epilepsy surgery.
Brain imaging in the assessment for epilepsy surgery.
复制标题
DOI：
10.1016/s1474-4422(15)00383-x
复制
发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Ourselin S
中科院分区：
文献类型：
--
作者：
Duncan JS;Winston GP;Koepp MJ;Ourselin S
脑成像在癫痫患者的术前评估中起着至关重要的作用。结构成像显示大多数局灶性癫痫的大脑病变。MRI采集的进步，包括扩散加权成像、采集后图像处理技术和成像数据的量化，正在提高病变检测的准确性。功能性磁共振成像可用于识别对语言、运动功能和记忆至关重要的皮质区域，纤维束成像可显示对这些功能至关重要的白色物质束，从而降低癫痫手术导致新疾病的风险。PET、SPECT、同步EEG和功能性MRI以及电和磁源成像可用于推断癫痫灶的定位并协助设计颅内EEG记录策略。将成像数据配准到公共空间的半自动方法的进展使得能够创建多模态三维患者特定数据集。这些技术显示出对正常和异常的结构和功能数据之间的复杂关系的证明的承诺，并可用于指导精确的颅内导航和手术的个体患者。
Brain imaging has a crucial role in the presurgical assessment of patients with epilepsy. Structural imaging reveals most cerebral lesions underlying focal epilepsy. Advances in MRI acquisitions including diffusion-weighted imaging, post-acquisition image processing techniques, and quantification of imaging data are increasing the accuracy of lesion detection. Functional MRI can be used to identify areas of the cortex that are essential for language, motor function, and memory, and tractography can reveal white matter tracts that are vital for these functions, thus reducing the risk of epilepsy surgery causing new morbidities. PET, SPECT, simultaneous EEG and functional MRI, and electrical and magnetic source imaging can be used to infer the localisation of epileptic foci and assist in the design of intracranial EEG recording strategies. Progress in semi-automated methods to register imaging data into a common space is enabling the creation of multimodal three-dimensional patient-specific datasets. These techniques show promise for the demonstration of the complex relations between normal and abnormal structural and functional data and could be used to direct precise intracranial navigation and surgery for individual patients.