Association of Optical Coherence Tomography-Measured Fibrovascular Ridge Thickness and Clinical Disease Stage in Retinopathy of Prematurity.
Association of Optical Coherence Tomography-Measured Fibrovascular Ridge Thickness and Clinical Disease Stage in Retinopathy of Prematurity.
复制标题
DOI：
10.1001/jamaophthalmol.2022.4173
复制
发表时间：
2022-10-13
影响因子：
8.1
通讯作者：
Jian, Yifan
中科院分区：
文献类型：
--
作者：
Nguyen, Thanh-Tin P.;Ni, Shuibin;Ostmo, Susan;Rajagopalan, Archeta;Coyner, Aaron S.;Woodward, Mani;Chiang, Michael F.;Jia, Yali;Huang, David;Campbell, J. Peter;Jian, Yifan
在扫频源光学相干断层扫描（OCT）测量的早产儿视网膜病变（ROP）中，正面成像的临床疾病分期与轴向纤维血管嵴厚度之间有什么关联？
在这项对25名患者的50只眼睛进行的横断面研究中，嵴厚度的OCT测量值与ROP疾病分期的更高临床分级增加相关。
研究结果表明，纤维血管嵴厚度可能是ROP诊断的一个可量化的生物标志物，对ROP疾病进展的纵向监测有用。
这项横断面研究评估了早产儿视网膜病变的临床诊断与光学相干断层扫描测量的纤维血管嵴厚度之间的关联。
准确诊断早产儿视网膜病变（ROP）对于及时治疗和降低失明风险至关重要。然而，ROP检查的各项内容是主观的和定性的。
为了评估光学相干断层扫描（OCT）在血管 - 无血管交界处得出的视网膜厚度测量值是否与ROP分期的临床诊断相关。
这项横断面纵向研究将由一名不知情的检查者根据OCT B扫描计算出的基于OCT的嵴厚度，与俄勒冈健康与科学大学（OHSU）医院新生儿重症监护病房（NICU）的两名不知情检查者使用传统分期分类以及更精细的连续量表进行的临床诊断进行了比较。纳入了2021年6月至2022年4月在OHSU NICU符合ROP筛查标准且获得监护人同意的婴儿。最终分析中包括每个患者每只眼睛的一个OCT容积和正面图像，其显示至少1 - 2个钟点的嵴。
使用有序和连续量表将OCT得出的嵴厚度与ROP分期的临床诊断进行比较。使用同一次就诊的20次重复检查评估重复性，并使用组内相关系数（ICC）和变异系数（CV）进行比较。使用广义估计方程将嵴厚度与有序类别进行比较，使用斯皮尔曼相关性将其与连续分期进行比较。
对25名患者的50只眼睛进行的总共128次单独的OCT眼部检查进行了分析。ICC为0.87，CV为7.0%。更高的疾病有序分类与OCT上更高的轴向嵴厚度相关，第1、2和3期的平均（标准差）厚度测量值分别为264.2（11.2）μm（P <.001）、334.2（11.4）μm（P <.001）和495.0（32.2）μm（P <.001），并且与连续分期标签相关（ρ = 0.739，P <.001）。
这些结果表明，基于OCT对ROP周边分期的量化可能是一种客观的、定量的生物标志物，可能对临床诊断和纵向监测有用，并可能对未来的疾病分类产生影响。
What is the association between clinical disease stage on en face imaging and the axial fibrovascular ridge thickness in retinopathy of prematurity (ROP) as measured by swept-source optical coherence tomography (OCT)? In this cross-sectional study of 50 eyes from 25 patients, OCT measurements of ridge thickness were associated with an increase in higher clinical classification of ROP disease stage. The findings indicate that fibrovascular ridge thickness may be a quantifiable biomarker for ROP diagnosis and useful for longitudinal monitoring of ROP disease progression. This cross-sectional study evaluates the association between the clinical diagnosis of retinopathy of prematurity and optical coherence tomography–measured fibrovascular ridge thickness. Accurate diagnosis of retinopathy of prematurity (ROP) is essential to provide timely treatment and reduce the risk of blindness. However, the components of an ROP examination are subjective and qualitative. To evaluate whether optical coherence tomography (OCT)–derived retinal thickness measurements at the vascular-avascular junction are associated with clinical diagnosis of ROP stage. This cross-sectional longitudinal study compared OCT-based ridge thickness calculated from OCT B-scans by a masked examiner to the clinical diagnosis of 2 masked examiners using both traditional stage classifications and a more granular continuous scale at the neonatal intensive care unit (NICU) of Oregon Health & Science University (OHSU) Hospital. Infants who met ROP screening criteria in the OHSU NICU between June 2021 and April 2022 and had guardian consent were included. One OCT volume and en face image per patient per eye showing at least 1 to 2 clock hours of ridge were included in the final analysis. Comparison of OCT-derived ridge thickness to the clinical diagnosis of ROP stage using an ordinal and continuous scale. Repeatability was assessed using 20 repeated examinations from the same visit and compared using intraclass correlation coefficient (ICC) and coefficient of variation (CV). Comparison of ridge thickness with ordinal categories was performed using generalized estimating equations and with continuous stage using Spearman correlation. A total of 128 separate OCT eye examinations from 50 eyes of 25 patients were analyzed. The ICC was 0.87 with a CV of 7.0%. Higher ordinal disease classification was associated with higher axial ridge thickness on OCT, with mean (SD) thickness measurements of 264.2 (11.2) μm (P < .001), 334.2 (11.4) μm (P < .001), and 495.0 (32.2) μm (P < .001) for stages 1, 2, and 3, respectively and with continuous stage labels (ρ = 0.739, P < .001). These results suggest that OCT-based quantification of peripheral stage in ROP may be an objective and quantitative biomarker that may be useful for clinical diagnosis and longitudinal monitoring and may have implications for disease classification in the future.
登录
查看更多内容
影响因子：
2.6
作者：
Nguyen TP;Ni S;Khan S;Wei X;Ostmo S;Chiang MF;Jia Y;Huang D;Jian Y;Campbell JP
通讯作者：
Campbell JP
影响因子：
13.7
作者：
Campbell JP;Kim SJ;Brown JM;Ostmo S;Chan RVP;Kalpathy-Cramer J;Chiang MF;of the Imaging and Informatics in Retinopathy of Prematurity Consortium
通讯作者：
of the Imaging and Informatics in Retinopathy of Prematurity Consortium
影响因子：
1.9
作者：
Zhang J;Liu Y;Mitsuhashi T;Matsuo T
通讯作者：
Matsuo T
影响因子：
3.4
作者：
Borkovkina, Svetlana;Camino, Acner;Jian, Yifan
通讯作者：
Jian, Yifan
影响因子：
3
作者：
Li, Peng;Liu, Jia
通讯作者：
Liu, Jia