Severe respiratory disorders in term neonates
Severe respiratory disorders in term neonates
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DOI：
10.1111/j.1365-3016.2007.00875.x
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发表时间：
2008-01-01
影响因子：
2.8
通讯作者：
Gouyon, B.
中科院分区：
文献类型：
--
作者：
Gouyon, Jean-Bernard;Ribakovsky, C.;Gouyon, B.
在足月新生儿中进行的呼吸系统疾病前瞻性人群研究很少。我们的目的是描述机械通气的呼吸系统疾病的足月新生儿和相关的危险因素，在一个区域为基础的研究之间的37和41周的活产。本研究采用前瞻性和回顾性研究方法，分别对14 813例胎龄37 ~ 38周和50 187例胎龄39 ~ 41周的新生儿重度呼吸系统疾病进行流行病学调查和统计学分析。总发生率新生儿机械通气短暂性呼吸急促（TTN）、呼吸窘迫综合征（RDS）和胎粪吸入综合征（MAS）的发生率分别为0.72 ‰ [95%CI 0.53 ‰，0.96 ‰]，0.38 ‰ [95%CI 0.25 ‰，0.57 ppm]和0.61 ppm [95% CI 0.44 ppm，0.84 ppm]。GA从37周增加到41周与RDS和TTN的发生率显著降低相关，而MAS无任何显著变化。多变量分析用于确定与严重呼吸系统疾病相关的独立因素：在37 - 38周组中- Apgar评分
Few prospective population-based studies of respiratory diseases have been conducted in term neonates. We aimed to describe mechanically ventilated respiratory disorders in term neonates and associated risk factors in a regional-based study of livebirths between 37 and 41 weeks. The study was prospective for epidemiological data recording, and retrospective for collecting additional data from charts of neonates with severe (mechanically ventilated) respiratory disorders.A total of 14 813 neonates with gestational age (GA) 37 - 38 weeks and 50 187 neonates with GA 39 - 41 weeks were included. The overall incidences (per thousand livebirths) of mechanically ventilated transient tachypnoea of the newborn (TTN) respiratory distress syndrome (RDS) and meconium aspiration syndrome (MAS) were 0.72 parts per thousand [95% CI 0.53 parts per thousand, 0.96 parts per thousand], 0.38 parts per thousand [95% CI 0.25 parts per thousand, 0.57 parts per thousand] and 0.61 [95% CI 0.44 parts per thousand, 0.84 parts per thousand], respectively. Increasing GA from 37 to 41 weeks was associated with a significant decrease in incidence of RDS and TTN without any significant change for MAS.Multivariable analysis was used to identify independent factors associated with severe respiratory disorders: in the 37 - 38 weeks group - Apgar score