CLINICAL-DISEASE ASSOCIATED WITH TRYPANOSOMA-THEILERI INFECTION IN A CALF IN IRELAND
CLINICAL-DISEASE ASSOCIATED WITH TRYPANOSOMA-THEILERI INFECTION IN A CALF IN IRELAND
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DOI：
10.1136/vr.132.26.653
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发表时间：
1993-06-26
影响因子：
2.2
通讯作者：
MURRAY, M
中科院分区：
文献类型：
--
作者：
DOHERTY, ML;WINDLE, H;MURRAY, M
一头四个月大的牛犊有发热、贫血、体重减轻和行为异常的临床病史。临床检查发现再生性贫血和淋巴细胞增多症的证据，这是以相对较大的B细胞群为特征的。小腿在观察期间临床恶化，其肩前和股前淋巴结肿大。血液涂片检查发现存在大量循环中的泰勒锥虫。血清学检查显示存在不变的、阶段特异性的锥虫表面抗原ISG70和抗ISG70抗体。ISG70首先在布鲁氏锥虫的血液中被发现，以前在T theileri中还没有发现。临床恢复与红细胞压积增加、循环中抗ISG70抗体水平降低以及循环中ISG70完全消失有关。
A four-month-old calf had a clinical history of pyrexia, anaemia, weight loss and behavioural abnormality. Clinical examination revealed evidence of regenerative anaemia and a lymphocytosis which was characterised by a relatively large B cell population. The calf deteriorated clinically while under observation and its prescapular and prefemoral lymph nodes became enlarged. Examination of a blood smear revealed the presence of a large number of circulating Trypanasoma theileri. Serological examination showed the presence of the invariant, stage-specific, trypanosome surface antigen, ISG70 and antibodies against ISG70. ISG70 was first identified in the bloodstream forms of Trypanosoma brucei and has not previously been found in T theileri. Clinical recovery was associated with an increase in packed cell volume, a decrease in the levels of circulating anti-ISG70 antibodies and the complete disappearance of circulating ISG70.