Drosophila S6 kinase: A regulator of cell size
Drosophila S6 kinase: A regulator of cell size
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DOI：
10.1126/science.285.5436.2126
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发表时间：
1999-09-24
期刊：
影响因子：
56.9
通讯作者：
Thomas, G
中科院分区：
文献类型：
--
作者：
Montagne, J;Stewart, MJ;Thomas, G
细胞增殖需要细胞生长，也就是说。细胞只有在达到临界大小后才会分裂。然而，细胞生长和保持其适当大小的机制仍然难以捉摸。缺乏S6激酶基因(DS6K)的果蝇表现出发育的极端延迟和身体尺寸的严重缩小。这些果蝇的细胞更小，而不是更少。这种作用是细胞自主的，表现在整个幼虫的发育过程中，与核糖体蛋白突变体(分钟)不同。因此，dS6K基因产物以细胞自主的方式调节细胞大小，而不影响细胞数量。
Cell proliferation requires cell growth; that is. cells only divide after they reach a critical size. However, the mechanisms by which cells grow and maintain their appropriate size have remained elusive. Drosophila deficient in the S6 kinase gene (dS6K) exhibited an extreme delay in development and a severe reduction in body size. These flies had smaller cells rather than fewer cells. The effect was cell-autonomous, displayed throughout Larval development, and distinct from that of ribosomal protein mutants (Minutes). Thus, the dS6K gene product regulates cell size in a cell-autonomous manner without impinging on cell number.