O-GlcNAcylation is a key regulator of multiple cellular metabolic pathways
O-GlcNAcylation is a key regulator of multiple cellular metabolic pathways
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DOI：
10.7717/peerj.11443
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发表时间：
2021-05
期刊：
影响因子：
2.7
通讯作者：
Hongshuo Zhang;Zhen Li;Yufei Wang;Yingyi Kong
中科院分区：
文献类型：
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作者：
Hongshuo Zhang;Zhen Li;Yufei Wang;Yingyi Kong
O-GlcNAc酰化修饰细胞核、细胞质和线粒体中丝氨酸或苏氨酸残基的蛋白质。它调节多种细胞生物学过程，并且异常的O-GlcNAc化与糖尿病、癌症、心血管疾病和神经退行性疾病相关。最近的证据表明，O-GlcNAc酰化作为营养传感器和信号整合器来调节代谢信号，并且其代谢的失调可能是疾病发病机制的重要指标。在此，我们回顾了主要代谢过程中的O-GlcNAc基化调控的文献，如葡萄糖代谢，线粒体氧化，脂质代谢和氨基酸代谢。我们讨论了它在生理过程中的作用，如细胞营养传感和稳态维持。O-GlcNAc酰化在多种代谢过程和途径中起着关键的调节作用。我们的综述将提供对O-GlcNAc化如何协调代谢和整合分子网络的更好理解。胞质中的UDP-GlcNAc被转运到线粒体，在线粒体中线粒体蛋白通过mOGT和莫加催化被动态地O-GlcNAc酰化。此外，细胞质中的O-GlcNAc修饰的艾德蛋白也易位至线粒体。直接或间接调节影响多种细胞过程的不同信号传导途径。
O -GlcNAcylation modi fi es proteins in serine or threonine residues in the nucleus, cytoplasm, and mitochondria. It regulates a variety of cellular biological processes and abnormal O -GlcNAcylation is associated with diabetes, cancer, cardiovascular disease, and neurodegenerative diseases. Recent evidence has suggested that O -GlcNAcylation acts as a nutrient sensor and signal integrator to regulate metabolic signaling, and that dysregulation of its metabolism may be an important indicator of pathogenesis in disease. Here, we review the literature focusing on O -GlcNAcylation regulation in major metabolic processes, such as glucose metabolism, mitochondrial oxidation, lipid metabolism, and amino acid metabolism. We discuss its role in physiological processes, such as cellular nutrient sensing and homeostasis maintenance. O -GlcNAcylation acts as a key regulator in multiple metabolic processes and pathways. Our review will provide a better understanding of how O -GlcNAcylation coordinates metabolism and integrates molecular networks. UDP-GlcNAc in the cytoplasm is transported to mitochondria where mitochondrial proteins are dynamically O-GlcNAcylated via mOGT and mOGA cata-lysis. In addition, O-GlcNAc modi fi ed proteins in the cytoplasm are also translocated to mitochondria. directly or indirectly regulates different signaling pathways affecting a variety of cellular processes.