Relationship between calcium, lactose, vitamin D, and dairy products and ovarian cancer
Relationship between calcium, lactose, vitamin D, and dairy products and ovarian cancer
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DOI：
10.1207/s15327914nc5601_4
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发表时间：
2006-01-01
影响因子：
2.9
通讯作者：
Schatzkin, Arthur
中科院分区：
文献类型：
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作者：
Koralek, Daniel O.;Bertone-Johnson, Elizabeth R.;Schatzkin, Arthur
很少有关于乳制品、钙、维生素D和乳糖摄入量与卵巢癌之间关系的前瞻性研究，结果在很大程度上不一致。最近的两项研究发现，经常食用乳制品以及高钙或乳糖摄入量会显着增加风险。作者调查了这些食物和营养素与乳腺癌检测示范项目随访队列中31，925名受试者的卵巢癌风险之间的关系。使用考克斯比例风险模型估计经年龄、产次和其他因素校正的多变量（MV）相对风险（RR）。在平均8.3年的随访中，146例卵巢癌病例被证实。较高的乳制品总摄入量（比较每天四份或更多份与每天少于一份）与卵巢癌风险的统计学显著降低相关，尽管趋势不显著（MV RR = 0.42; 95%置信区间（CI）= 0.20 - 0.89;趋势P = 0.07）。比较极端四分位数，我们观察到高膳食钙摄入量与卵巢癌之间的统计学上无显著负相关（RR = 0.67; 95%CI = 0.43，1.04;趋势P = 0.08）。没有发现特定乳制品、乳糖或维生素D的消费与卵巢癌风险之间存在统计学显著关系。膳食钙降低卵巢癌风险的可能性值得进一步评估。
Few prospective studies of the relationship between intake of dairy foods, calcium, vitamin D, and lactose and ovarian cancer have been conducted, and results have been largely inconsistent. Two recent studies found significant increased risk with frequent dairy consumption and perhaps with high intakes of calcium or lactose. The authors investigated the association between these foods and nutrients and ovarian cancer risk among 31,925 subjects in the Breast Cancer Detection Demonstration Project follow-up cohort. Multivariable (MV) relative risks (RRs) adjusted for age, parity, and other factors were estimated using Cox proportional hazards models. Over an average follow-up of 8.3 yr, 146 incident ovarian cancer cases were confirmed. Higher intakes of total dairy food (comparing four or more servings per day vs. less than one serving per day) were associated with a statistically significant decreased risk of ovarian cancer, although the trend was not significant (MV RR = 0.42; 95% confidence interval (CI) = 0.20 - 0.89; P for trend = 0.07). Comparing extreme quartiles, we observed a statistically nonsignificant inverse association between high dietary calcium intake and ovarian cancer (RR = 0.67; 95% CI = 0.43, 1.04; P for trend = 0.08). No statistically significant relations were found for consumption of specific dairy foods, lactose, or vitamin D and ovarian cancer risk. The possibility of a decreased risk of ovarian cancer for dietary calcium merits further evaluation.