Cartilage thickening in early radiographic knee osteoarthritis: A within-person, between-knee comparison
Cartilage thickening in early radiographic knee osteoarthritis: A within-person, between-knee comparison
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DOI：
10.1002/acr.21719
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发表时间：
2012-11-01
影响因子：
4.7
通讯作者：
Eckstein, Felix
中科院分区：
文献类型：
--
作者：
Cotofana, Sebastian;Buck, Robert;Eckstein, Felix
目的通过对骨关节炎倡议参与者的膝关节横截面比较，确定X线片上明确骨赘（无关节间隙狭窄[JSN]）的存在是否与软骨厚度（分区域）增加相关。在前人研究的基础上，选择外侧负重股骨内侧髁（ecMF）和外侧负重股骨髁（ecLF）作为主要研究终点。（n = 4，796）1例膝关节显示明确的胫骨或股骨边缘骨赘，无JSN，对侧膝关节无放射学骨关节炎（OA）体征;这一点得到了专家中心读者的证实。在这些参与者中，软骨厚度测量在16股胫各膝关节亚区，基于矢状面双回波稳态水激发磁共振图像。使用专用软件确定固定屈曲X线片的特定位置关节间隙宽度。使用配对t检验和混合效应models.Results的61名参与者中，48%只有内侧骨赘，36%只有外侧骨赘，16%双间室骨赘与软骨thickness骨赘的位置特异性协会进行了评估。在ecMF（平均值+/- SD +71 +/- 223 mu moles，相当于增加+5.5%; P = 0.015）和ecLF（平均值+/- SD +64 +/- 195 mu moles，+4.1%; P = 0.013）中，有骨赘的膝关节的软骨显著厚于无骨赘的对侧膝关节。在其他亚区或关节间隙宽度方面，膝关节之间没有显著差异。ecMF和ecLF中的软骨厚度与同一（内侧或外侧）间室中的胫骨骨赘显著相关（P = 0.003）。结论早期X线片显示OA的膝关节比无OA的对侧膝关节显示更厚的软骨，特别是在具有边缘骨赘的间室的股骨外侧亚区。
Objective To determine whether the presence of definite osteophytes (in the absence of joint space narrowing [JSN]) on radiographs is associated with (subregional) increases in cartilage thickness in a within-person, between-knee cross-sectional comparison of participants in the Osteoarthritis Initiative. Based on previous results, the external weight-bearing medial femoral condyle (ecMF) and external weight-bearing lateral femoral condyle (ecLF) subregions were selected as primary end points.Methods Both knees of 61 Osteoarthritis Initiative participants (n = 4,796) displayed definite tibial or femoral marginal osteophytes and no JSN in 1 knee, and no signs of radiographic osteoarthritis (OA) in the contralateral knee; this was confirmed by an expert central reader. In these participants, cartilage thickness was measured in 16 femorotibial subregions of each knee, based on sagittal double-echo steady-state with water excitation magnetic resonance images. Location-specific joint space width from fixed-flexion radiographs was determined using dedicated software. Location-specific associations of osteophytes with cartilage thickness were evaluated using paired t-tests and mixed-effects models.Results Of the 61 participants, 48% had only medial osteophytes, 36% only lateral osteophytes, and 16% bicompartmental osteophytes. The knees with osteophytes had significantly thicker cartilage than contralateral knees without osteophytes in the ecMF (mean +/- SD +71 +/- 223 mu moles, equivalent to an increase of +5.5%; P = 0.015) and ecLF (mean +/- SD +64 +/- 195 mu moles, +4.1%; P = 0.013). No significant differences between knees were noted in other subregions or in joint space width. Cartilage thickness in the ecMF and ecLF was significantly associated with tibial osteophytes in the same (medial or lateral) compartment (P = 0.003).Conclusion The knees with early radiographic OA display thicker cartilage than (contralateral) knees without radiographic findings of OA, specifically in the external femoral subregions of compartments with marginal osteophytes.