Learning RNA structure prediction from crowd-designed RNAs.

Learning RNA structure prediction from crowd-designed RNAs.
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DOI:
10.1038/s41592-022-01607-y
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发表时间:
2022-10
期刊:
影响因子:
48
通讯作者:
Das, Rhiju
Das, Rhiju
中科院分区:
生物学1区
文献类型:
--
作者:
Wayment-Steele, Hannah K.;Das, Rhiju

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由公民科学家设计并在高通量实验中进行探测的RNA分子突显了RNA折叠算法在预测RNA结构集合的能力方面的差异。这些数据集被用来训练一种新的算法,该算法在一组独立的数据集上表现出了更好的性能,包括在细胞中探测的病毒基因组RNA和mRNA。
RNA molecules designed by citizen scientists and probed in high-throughput experiments highlighted discrepancies among RNA folding algorithms in their ability to predict RNA structure ensembles. These datasets were used to train a new algorithm that demonstrated improved performance in a collection of independent datasets, including viral genomic RNAs and mRNAs probed in cells.
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